{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"submitter":["Amiee Potter"],"organism":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-2509"],"description":["We hypothesize that, the mTOR pathway is a dominant pathway in cultured keloid and hypertrophy scar fibriblasts compared to normal skin cells. Certain pathway changes can be detected after medication treatment.  Global gene expression in RNA samples from rapamycin and tacrolimus treated fibroblasts (from normal skin and hypertrophic scars, keloid scars) is assayed to study the possibility to use mTOR inhibitors as potential drug to treat abnormal scarring. We investigated the difference between normal wound healing and hypertrophic scars and keloids as well."],"repository":["biostudies-arrayexpress"],"sample_protocol":["Scaning - GPSR at OHSU Scanned","Nucleic Acid Extraction - Kit"],"figure_sub":["MIAME Score","Raw Data","Organization","Assays and Data","Processed Data","MAGE-TAB Files","Array Designs"],"data_protocol":["Data Transformation - Illumina GenomeStudio Software"],"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"study_type":["transcription profiling by array"],"species":["Homo sapiens"],"pubmed_title":["Tacrolimus fails to regulate collagen expression in dermal fibroblasts"],"pubmed_authors":["Amiee Potter","Wong VW, You F, Januszyk M, Kuang AA"],"additional_accession":[]},"is_claimable":false,"name":"The Role of the Mammalian Target of Rapamycin in Keloid and Hypertrophic Scars","description":"We hypothesize that, the mTOR pathway is a dominant pathway in cultured keloid and hypertrophy scar fibriblasts compared to normal skin cells. Certain pathway changes can be detected after medication treatment.  Global gene expression in RNA samples from rapamycin and tacrolimus treated fibroblasts (from normal skin and hypertrophic scars, keloid scars) is assayed to study the possibility to use mTOR inhibitors as potential drug to treat abnormal scarring. We investigated the difference between normal wound healing and hypertrophic scars and keloids as well.","dates":{"release":"2014-05-20T00:00:00Z","modification":"2022-02-23T18:42:48.399Z","creation":"2022-02-23T18:42:48.399Z"},"accession":"E-MTAB-2509","cross_references":{"EFO":["EFO_0002768"]}}