{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"submitter":["Tesfaye Mengiste"],"organism":["Arabidopsis thaliana"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-4281"],"description":["Role of MED18 in plant immunity, response to hormones and flowering time. We conducted RNA-seq analysis to understand the extent of the regulatory impact of MED18 and determine whether the phenotypes observed in the med18 mutant were correlated with specific defects in gene expression. RNA- seq data from mock or B. cinerea-inoculated plants were compared"],"repository":["biostudies-arrayexpress"],"sample_protocol":["Sequencing - Illumina HiScanSQ"],"figure_sub":["Organization","MINSEQE Score","Assays and Data","MAGE-TAB Files"],"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"instrument_platform":["Illumina HiScanSQ"],"pubmed_abstract":["Mediator is an evolutionarily conserved transcriptional regulatory complex. Mechanisms of Mediator function are poorly understood. Here we show that Arabidopsis MED18 is a multifunctional protein regulating plant immunity, flowering time and responses to hormones through interactions with distinct transcription factors. MED18 interacts with YIN YANG1 to suppress disease susceptibility genes glutaredoxins GRX480, GRXS13 and thioredoxin TRX-h5. Consequently, yy1 and med18 mutants exhibit deregulated expression of these genes and enhanced susceptibility to fungal infection. In addition, MED18 interacts with ABA INSENSITIVE 4 and SUPPRESSOR OF FRIGIDA4 to regulate abscisic acid responses and flowering time, respectively. MED18 associates with the promoter, coding and terminator regions of targ"],"study_type":["RNA-seq of coding RNA"],"species":["Arabidopsis thaliana"],"pubmed_title":["MED18 interaction with distinct transcription factors regulates multiple plant functions"],"pubmed_authors":["Lai Z, Schluttenhofer CM, Bhide K, Shreve J, Thimmapuram J, Lee SY, Yun DJ, Mengiste T","Tesfaye Mengiste"],"additional_accession":[]},"is_claimable":false,"name":"Arabidopsis thalianaTranscriptome or Gene expression","description":"Role of MED18 in plant immunity, response to hormones and flowering time. We conducted RNA-seq analysis to understand the extent of the regulatory impact of MED18 and determine whether the phenotypes observed in the med18 mutant were correlated with specific defects in gene expression. RNA- seq data from mock or B. cinerea-inoculated plants were compared","dates":{"release":"2014-01-24T00:00:00Z","modification":"2022-02-04T07:49:40.973Z","creation":"2022-02-04T07:49:40.973Z"},"accession":"E-MTAB-4281","cross_references":{"pubmed":["24451981"],"ENA":["SRP033777"],"EFO":["EFO_0004170","EFO_0003738"],"doi":["10.1038/ncomms4064"]}}