{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"submitter":["Janos Demeter"],"organism":["Mus musculus"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-SMDB-2870"],"description":["This logical set encompases several 8hr timecourses (0,1,2,4,8 hrs) and their replicates.  All correspond to treatments of bone marrow derived macrophages."],"repository":["biostudies-arrayexpress"],"figure_sub":["MIAME Score","Raw Data","Organization","Assays and Data","MAGE-TAB Files","Array Designs"],"data_protocol":["Feature Extraction - Title: Feature Extraction. Description: Software and parameters for feature extraction."],"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"pubmed_abstract":["Innate and adaptive immunity depends critically on host recognition of pathogen-associated molecules. Toll-like receptors (TLRs) are key mediators of pathogen surveillance at the cell or phagocytic vacuole surface. However, mechanisms underlying recognition of pathogens in other cellular compartments remain unclear, and responses elicited by cytosolic challenge are poorly characterized. We therefore used mouse cDNA microarrays to investigate gene expression triggered by infection of bone marrow-derived macrophages with cytosol- and vacuole-localized Listeria monocytogenes (Lm), a model cytosolic pathogen. The resulting gene expression program included two basic categories of induced genes: an \"early/persistent\" cluster consistent with NF-kappaB-dependent responses downstream of TLRs, and a"],"study_type":["transcription profiling by array"],"species":["Mus musculus"],"pubmed_title":["A specific gene expression program triggered by Gram-positive bacteria in the cytosol."],"pubmed_authors":["Paul Fawcett","McCaffrey RL, Fawcett P, O","Janos Demeter"],"additional_accession":[]},"is_claimable":false,"name":"Transcription profiling of mouse host response to listeria infection, time series","description":"This logical set encompases several 8hr timecourses (0,1,2,4,8 hrs) and their replicates.  All correspond to treatments of bone marrow derived macrophages.","dates":{"release":"2005-11-03T00:00:00Z","modification":"2022-03-04T17:38:13.265Z","creation":"2022-03-04T17:38:13.265Z"},"accession":"E-SMDB-2870","cross_references":{"pubmed":["15269347"],"EFO":["EFO_0002768"],"doi":["15269347"]}}