{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"submitter":["Janos Demeter"],"organism":["Salmonella enterica serovar Typhimurium"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-SMDB-3619"],"description":["This experiment set includes all the input and spleen pooled arrays from the first negative selection passaged through 129SvJ mice and represents the 28-day timepoint.  \"P.2 input\" is the same thing as the P.1 output while \"P.2 output\" represents a sample of the 28-day output repassaged through mice for an additional 28 days.  Analysis demonstrated that there was no significant difference between the P.1 and P.2 re-passaged 28-day samples so they are treated the same."],"repository":["biostudies-arrayexpress"],"figure_sub":["MIAME Score","Raw Data","Organization","Assays and Data","MAGE-TAB Files","Array Designs"],"data_protocol":["Feature Extraction - Title: Feature Extraction. Description: Software and parameters for feature extraction."],"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"pubmed_abstract":["A microarray-based negative selection screen was performed to identify Salmonella enterica serovar Typhimurium (serovar Typhimurium) genes that contribute to long-term systemic infection in 129X1/SvJ (Nramp1(r)) mice. A high-complexity transposon-mutagenized library was used to infect mice intraperitoneally, and the selective disappearance of mutants was monitored after 7, 14, 21, and 28 d postinfection. One hundred and eighteen genes were identified to contribute to serovar Typhimurium infection of the spleens of mice by 28 d postinfection. The negatively selected mutants represent many known aspects of Salmonella physiology and pathogenesis, although the majority of the identified genes are of putative or unknown function. Approximately 30% of the negatively selected genes correspond to "],"study_type":["transcription profiling by array"],"species":["Salmonella enterica serovar Typhimurium"],"pubmed_title":["Genome-Wide Screen for Salmonella Genes Required for Long-Term Systemic Infection of the Mouse."],"pubmed_authors":["Janos Demeter","Kaman Chan","Trevor D. Lawley, Kaman Chan, Lucinda J. Thompson, Charles C. Kim, Gregory R. Govoni, Denise M. Monack"],"additional_accession":[]},"is_claimable":false,"name":"Transcription profiling of Salmonella passaged through 129SvJ mice to identify genes required for long term systemic infection","description":"This experiment set includes all the input and spleen pooled arrays from the first negative selection passaged through 129SvJ mice and represents the 28-day timepoint.  \"P.2 input\" is the same thing as the P.1 output while \"P.2 output\" represents a sample of the 28-day output repassaged through mice for an additional 28 days.  Analysis demonstrated that there was no significant difference between the P.1 and P.2 re-passaged 28-day samples so they are treated the same.","dates":{"release":"2006-06-06T00:00:00Z","modification":"2022-02-04T01:23:22.148Z","creation":"2022-02-04T01:23:22.148Z"},"accession":"E-SMDB-3619","cross_references":{"pubmed":["16518469"],"EFO":["EFO_0002768"],"doi":["16518469"]}}