biostudies-arrayexpressPhilippe DESSENangioimmunoblastic T-cell lymphomaHomo sapienshttps://www.ebi.ac.uk/biostudies/studies/E-TABM-1161Copy number analysis in an AITL samplebiostudies-arrayexpressNucleic Acid Extraction - Qiagen protocolHybridization - According to Agilent protocolsLabeling - Cy5 and Cy3 labelling (according to manufacturer)MIAME ScoreRaw DataOrganizationAssays and DataProcessed DataAdditional FilesMAGE-TAB FilesArray DesignsAssay Data Transformation - Agilent Freature Extraction 10.5.1Image Adquisition - Agilent Technologies Scanner G2505C at 2 mu resolutionMetabolomicsUnknownTranscriptomicsGenomicsProteomicsLoss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation (TET)2 gene have been described in various human myeloid malignancies. We report that inactivation of Tet2 in mouse perturbs both early and late steps of hematopoiesis including myeloid and lymphoid differentiation in a cell-autonomous manner, endows the cells with competitive advantage, and eventually leads to the development of malignancies. We subsequently observed TET2 mutations in human lymphoid disorders. TET2 mutations could be detected in immature progenitors endowed with myeloid colony-forming potential. Our results show that the mutations present in lymphoid tumor cells may occur at both early and later steps of lymphoid development and indicate that impairment of TET2 function or/and expressicomparative genomic hybridization by arrayHomo sapiensTET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesisPhilippe DESSENQuivoron C, Couronné L, Della Valle V, Lopez CK, Plo I, Wagner-Ballon O, Do Cruzeiro M, Delhommeau F, Arnulf B, Stern MH, Godley L, Opolon P, Tilly H, Solary E, Duffourd Y, Dessen P, Merle-Beral H, Nguyen-Khac F, Fontenay M, Vainchenker W, Bastard C, Mercher T, Bernard OAfalseIGR_OB1_T_CELL_LYMPHOMACopy number analysis in an AITL sample2011-11-02T00:00:00Z2022-11-23T03:45:27.157Z2022-01-26T00:14:25.901ZE-TABM-116121723201EFO_000074910.1016/j.ccr.2011.06.003