{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"submitter":["Maria Krestyaninova"],"organism":["Homo sapiens"],"software":["MicroArraySuite 5.0"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-TABM-325"],"description":["Fat biopsies from normoglycaemic twins were analysed on Affymetrix arrays"],"repository":["biostudies-arrayexpress"],"sample_protocol":["Sample Processing - Fat biopsy abdominal RNA was extracted from twins for microarray analysis","Labeling - No protocol provided.","Nucleic Acid Extraction - RNA integrity value is a number 1-10","Hybridization - No protocol provided."],"figure_sub":["MIAME Score","Raw Data","Organization","Assays and Data","Processed Data","Additional Files","MAGE-TAB Files","Array Designs"],"data_protocol":["Assay Data Transformation - Data was normalized using RMA method.","Feature Extraction - Title: Affymetrix CEL analysis. Description:"],"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"pubmed_abstract":["Metabolic Syndrome (MetS) is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abdominal (ABD) and gluteal (GLU) adipose tissue, and whole blood (WB), from 29 MetS cases and 44 controls. Co-expression network analysis for each tissue independently identified nine, six, and zero MetS-associated modules of coexpressed genes in ABD, GLU, and WB, respectively. Of 8,992 probesets expressed in ABD or GLU, 685 (7.6%) were expressed in ABD and 51 (0.6%) in GLU only. Differential eigengene network analysis of 8,256 shared probesets detected 22 shared modules with high preservation across adipose depots (D(ABD-GLU) = 0.89), seven of w"],"species":["Homo sapiens"],"pubmed_title":["Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes."],"pubmed_authors":["Maria Krestyaninova","Min JL, Nicholson G, Halgrimsdottir I, Almstrup K, Petri A, Barrett A, Travers M, Rayner NW, Magi R, Pettersson FH, Broxholme J, Neville MJ, Wills QF, Cheeseman J, GIANT Consortium, MolPAGE Consortium, Allen M, Holmes CC, Spector TD, Fleckner J, McCarthy MI, Karpe F, Lindgren CM, Zondervan KT."],"additional_accession":[]},"is_claimable":false,"name":"Transcription profiling of fat biopsies from normoglycaemic twins (MolPAGE study)","description":"Fat biopsies from normoglycaemic twins were analysed on Affymetrix arrays","dates":{"release":"2008-08-30T00:00:00Z","modification":"2022-11-23T01:32:23.35Z","creation":"2022-02-03T06:34:19.104Z"},"accession":"E-TABM-325","cross_references":{"pubmed":["22383892"],"doi":["10.1371/journal.pgen.1002505"]}}