biostudies-arrayexpressMetabolomicsUnknownTranscriptomicsGenomicsProteomicsCarolyn de Graafc-Myb is a transcription factor with functions in many hematopoietic lineages. c-Myb-deficient mice display reduced numbers of B cells; however, it is unknown what role c-Myb plays in B lymphopoiesis because no critical target genes have been identified in the B-cell lineage. We demonstrate that conditional deletion of c-Myb in B-cell progenitors completely abolishes B-cell development. c-Myb is required for lymphoid progenitors to respond to the cytokines interleukin-7 and thymic stromal lymphopoietin; in the absence of sufficient c-Myb activity, mice display a B lymphopenia that closely resembles that observed in interleukin-7 receptor alpha-deficient animals. Analysis of the multipotent progenitor compartment indicates that c-Myb is also required for up-regulation of multiple lymphoid-atranscription profiling by arrayMus musculusMus musculushttps://www.ebi.ac.uk/biostudies/studies/E-TABM-690A comparison of WT pro B cells to Myb Plt4/+ Pro B Cellsbiostudies-arrayexpressCritical roles for c-Myb in lymphoid priming and early B-cell developmentMIAME ScoreOrganizationAssays and DataMAGE-TAB FilesArray DesignsGreig, Kylie T.; de Graaf, Carolyn A.; Murphy, James M.; Carpinelli, Marina R.; Pang, Swee Heng Milon; Frampton, Jon; Kile, Benjamin T.; Hilton, Douglas J.; Nutt, Stephen L.Carolyn de GraaffalseTranscription profiling of mouse wildtype and Myb Plt4/+ Pro B cellsA comparison of WT pro B cells to Myb Plt4/+ Pro B Cells2009-12-31T00:00:00Z2022-02-02T14:30:07.609Z2022-02-02T14:30:07.609ZE-TABM-69020130238EFO_000276820130238