biostudies-arrayexpressNorman LeeRattus rattushttps://www.ebi.ac.uk/biostudies/studies/E-TIGR-80Examination of gene expression associated with hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SSYBN) rat strain. SSYBN rats are derived from introgression of chromosome Y from BN rats into the SS genetic background.biostudies-arrayexpressLabeling - Title: SOP_M004. Description:Nucleic Acid Extraction - Title: MCW_RNA_preparation. Description: Animal handling and RNA preparation at the Medical College of Wisconsin. I. Animal handling at Medical College of Wisconsin == Forty-eight rats are used per study, with eight groups of six rats each. 6 Female parental normoxic 6 Male parental normoxic 6 Female parental hypoxic 6 Male parental hypoxic 6 Female consomic normoxic 6 Male consomic normoxic 6 Female consomic hypoxic 6 Male consomic hypoxic == Each group of six rats is divided into two pools of three animals each, with each pool containing tissues from 3 rats. Pool A Pool B == Four individual tissues from all three animals are pooled together. Heart Kidney Liver Lung pool pool pool pool 48 rats / 3 rats per pool X 4 tissues = 64 pooled samples *Note - In some cMIAME ScoreRaw DataOrganizationAssays and DataMAGE-TAB FilesArray DesignsMetabolomicsUnknownTranscriptomicsGenomicsProteomicsCardiovascular disorders are influenced by genetic and environmental factors. The TIGR rodent expression web-based resource (TREX) contains over 2,200 microarray hybridizations, involving over 800 animals from 18 different rat strains. These strains comprise genetically diverse parental animals and a panel of chromosomal substitution strains derived by introgressing individual chromosomes from normotensive Brown Norway (BN/NHsdMcwi) rats into the background of Dahl salt sensitive (SS/JrHsdMcwi) rats. The profiles document gene-expression changes in both genders, four tissues (heart, lung, liver, kidney) and two environmental conditions (normoxia, hypoxia). This translates into almost 400 high-quality direct comparisons (not including replicates) and over 100,000 pairwise comparisons. As eatranscription profiling by arrayRattus rattusPhysiogenomic resources for rat models of heart, lung and blood disordersAnne KwitekNorman LeeHongying WangJoseph WhiteRenae L Malek, Hong-ying Wang, Anne E Kwitek, Andrew S Greene, Nirmal Bhagabati, Gretta Borchardt, Lisa Cahill, Tracey Currier, Bryan Frank, Xianping Fu, Michael Hasinoff, Eleanor Howe, Noah Letwin, Truong V Luu, Alexander Saeed, Hedieh Sajadi, Steven L Salzberg, Razvan Sultana, Mathangi Thiagarajan, Jennifer Tsai, Kathleen Veratti, Joseph White, John Quackenbush, Howard J Jacob and Norman H Lee';falseTranscription profiling of rat lung response to hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SSYBN) rat strainExamination of gene expression associated with hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SSYBN) rat strain. SSYBN rats are derived from introgression of chromosome Y from BN rats into the SS genetic background.2005-01-01T00:00:00Z2022-02-03T10:57:43.673Z2022-02-03T10:57:43.673ZE-TIGR-8016415889EFO_000276816415889