{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tabrizi MEA"],"funding":["Aston University"],"pagination":["711"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10000480"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["The protein ezrin has been shown to enhance cancer cell motility and invasion leading to malignant behaviours in solid tumours, but a similar regulatory function in the early physiological reproduction state is, however, much less clear. We speculated that ezrin may play a key role in promoting first-trimester extravillous trophoblast (EVT) migration/invasion. Ezrin, as well as its Thr567 phosphorylation, were found in all trophoblasts studied, whether primary cells or lines. Interestingly, the proteins were seen in a distinct cellular localisation in long, extended protrusions in specific regions of cells. Loss-of-function experiments were carried out in EVT HTR8/SVneo and Swan71, as well as primary cells, using either ezrin siRNAs or the phosphorylation Thr567 inhibitor NSC668394, result"],"journal":["Cells"],"pubmed_title":["Ezrin and Its Phosphorylated Thr567 Form Are Key Regulators of Human Extravillous Trophoblast Motility and Invasion."],"pmcid":["PMC10000480"],"funding_grant_id":["Research Group and Biomedical Sciences Research funding schemes at Aston University and a Life and Health Sciences PhD studentship to M.E.A.T."],"pubmed_authors":["Gross SR","Gupta JK","Tabrizi MEA"],"additional_accession":[]},"is_claimable":false,"name":"Ezrin and Its Phosphorylated Thr567 Form Are Key Regulators of Human Extravillous Trophoblast Motility and Invasion.","description":"The protein ezrin has been shown to enhance cancer cell motility and invasion leading to malignant behaviours in solid tumours, but a similar regulatory function in the early physiological reproduction state is, however, much less clear. We speculated that ezrin may play a key role in promoting first-trimester extravillous trophoblast (EVT) migration/invasion. Ezrin, as well as its Thr567 phosphorylation, were found in all trophoblasts studied, whether primary cells or lines. Interestingly, the proteins were seen in a distinct cellular localisation in long, extended protrusions in specific regions of cells. Loss-of-function experiments were carried out in EVT HTR8/SVneo and Swan71, as well as primary cells, using either ezrin siRNAs or the phosphorylation Thr567 inhibitor NSC668394, result","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-26T14:08:18.973Z","creation":"2025-02-19T02:42:45.013Z"},"accession":"S-EPMC10000480","cross_references":{"pubmed":["36899847"],"doi":["10.3390/cells12050711"]}}