{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu L"],"funding":["Shanxi Key Laboratory of Minor Crops Germplasm Innovation and Molecular Breeding, Shanxi Agricultural University","Shanxi Agricultural University Youth Science and Technology Innovation Fund"],"pagination":["1101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10000491"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT) promotes gastrointestinal motility. In this study, the effect of MJGT ethanol extract (MJGT_EE) in treating irritable bowel syndrome with constipation (IBS-C) in a rat model constructed via maternal separation combined with an ice water stimulation was investigated. First, a successful model construction was confirmed through the determination of the fecal water content (FWC) and the smallest colorectal distension (CRD) volume. Then, the overall regulatory effects of MJGT_EE on the gastrointestinal tract were preliminarily evaluated through gastric emptying and small intestinal propulsion tests. Our findings indicated that MJGT_EE significantly increased FWC (<i>p</i> < 0.01) and the smallest CRD volum"],"journal":["Foods (Basel, Switzerland)"],"pubmed_title":["Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway."],"pmcid":["PMC10000491"],"funding_grant_id":["2016020","(202105D121010)","(2016020)","202105D121010"],"pubmed_authors":["Wu L","Jin X","Qiao X","Chen Z","Gao L","Cui X","Gao J","Zhang L"],"additional_accession":[]},"is_claimable":false,"name":"Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway.","description":"In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT) promotes gastrointestinal motility. In this study, the effect of MJGT ethanol extract (MJGT_EE) in treating irritable bowel syndrome with constipation (IBS-C) in a rat model constructed via maternal separation combined with an ice water stimulation was investigated. First, a successful model construction was confirmed through the determination of the fecal water content (FWC) and the smallest colorectal distension (CRD) volume. Then, the overall regulatory effects of MJGT_EE on the gastrointestinal tract were preliminarily evaluated through gastric emptying and small intestinal propulsion tests. Our findings indicated that MJGT_EE significantly increased FWC (<i>p</i> < 0.01) and the smallest CRD volum","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-04-08T14:20:23.834Z","creation":"2025-02-19T02:38:20.766Z"},"accession":"S-EPMC10000491","cross_references":{"pubmed":["36900618"],"doi":["10.3390/foods12051101"]}}