biostudies-literatureUnknown15(5)Saito Y<h4>Purposes</h4>To establish the appropriate staging system and assess the role of curative thyroidectomy alone (Surgery) vs. involved-site radiation therapy after open biopsy (OB-ISRT) in stage IE mucosa-associated lymphoid tissue (MALT) lymphoma.<h4>Methods</h4>We examined the Tokyo Classification as a modified classification. This retrospective cohort study included 256 patients with thyroid MALT lymphoma; 137 underwent standard therapy (i.e., OB-ISRT) and were enrolled for the Tokyo classification. Sixty stage IE patients with the same diagnosis were examined to compare Surgery with OB-ISRT.<h4>Results</h4>Overall survival (<i>p</i> = 0.0092) and relapse-free survival (0.00113) were significantly better in stage IE vs. stage IIE under the Tokyo classification. No OB-ISRT and Surgery pCancers1451https://www.ebi.ac.uk/biostudies/studies/S-EPMC10000773biostudies-literatureRole of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo Classification.PMC10000773Akaishi JNagahama MYoshihara ASuzuki NSaito YMatsuzu KSugino KFukushita MKitagawa WYoshioka KSaito NNoh JYOkamura RSuzuki AIto KTakami HWatanabe NHames KYTomoda CNarimatsu HKameyama KMasaki CMatsumoto MfalseRole of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo Classification.<h4>Purposes</h4>To establish the appropriate staging system and assess the role of curative thyroidectomy alone (Surgery) vs. involved-site radiation therapy after open biopsy (OB-ISRT) in stage IE mucosa-associated lymphoid tissue (MALT) lymphoma.<h4>Methods</h4>We examined the Tokyo Classification as a modified classification. This retrospective cohort study included 256 patients with thyroid MALT lymphoma; 137 underwent standard therapy (i.e., OB-ISRT) and were enrolled for the Tokyo classification. Sixty stage IE patients with the same diagnosis were examined to compare Surgery with OB-ISRT.<h4>Results</h4>Overall survival (<i>p</i> = 0.0092) and relapse-free survival (0.00113) were significantly better in stage IE vs. stage IIE under the Tokyo classification. No OB-ISRT and Surgery p2023-01-01T00:00:00Z2023 Feb2025-06-28T03:06:15.873Z2025-06-28T03:06:15.873ZS-EPMC100007733690024210.3390/cancers15051451