{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Andric F"],"funding":["The Swedish Research Council, the Swedish Cancer Society, the Bengt Ihre Foundation, the Swedish state under the ALF agreement."],"pagination":["1457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10001362"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(5)"],"pubmed_abstract":["The incidence of left-sided colon and rectal cancer in young people are increasing worldwide, but its causes are poorly understood. It is not clear if the tumor microenvironment is dependent on age of onset, and little is known about the composition of tumor-infiltrating T cells in early-onset colorectal cancer (EOCRC). To address this, we investigated T-cell subsets and performed gene expression immune profiling in sporadic EOCRC tumors and matched average-onset colorectal cancer (AOCRC) tumors. Left-sided colon and rectal tumors from 40 cases were analyzed; 20 EOCRC (<45 years) patients were matched 1:1 to AOCRC (70-75 years) patients by gender, tumor location, and stage. Cases with germline pathogenic variants, inflammatory bowel disease or neoadjuvant-treated tumors were excluded. For "],"journal":["Cancers"],"pubmed_title":["Immune Microenvironment in Sporadic Early-Onset versus Average-Onset Colorectal Cancer."],"pmcid":["PMC10001362"],"funding_grant_id":["ALFGBG-874451"],"pubmed_authors":["Wettergren Y","Tumusiime G","Ljungman D","Cusack JC","Szeponik L","Quiding-Jarbrink M","Andric F","Al-Fairouzi A","Bexe-Lindskog E"],"additional_accession":[]},"is_claimable":false,"name":"Immune Microenvironment in Sporadic Early-Onset versus Average-Onset Colorectal Cancer.","description":"The incidence of left-sided colon and rectal cancer in young people are increasing worldwide, but its causes are poorly understood. It is not clear if the tumor microenvironment is dependent on age of onset, and little is known about the composition of tumor-infiltrating T cells in early-onset colorectal cancer (EOCRC). To address this, we investigated T-cell subsets and performed gene expression immune profiling in sporadic EOCRC tumors and matched average-onset colorectal cancer (AOCRC) tumors. Left-sided colon and rectal tumors from 40 cases were analyzed; 20 EOCRC (<45 years) patients were matched 1:1 to AOCRC (70-75 years) patients by gender, tumor location, and stage. Cases with germline pathogenic variants, inflammatory bowel disease or neoadjuvant-treated tumors were excluded. For ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T09:53:26.665Z","creation":"2025-04-04T09:53:26.665Z"},"accession":"S-EPMC10001362","cross_references":{"pubmed":["36900249"],"doi":["10.3390/cancers15051457"]}}