biostudies-literatureUnknown20(5)Pena-Vazquez O<h4>Background</h4>CrossFit is known as a functional fitness training high-intensity exercise to improve physical performance. The most studied polymorphisms are the ACTN3 R577X gene, known for speed, power, and strength, and ACE I/D, related to endurance and strength. The present investigation analyzed the effects of training on ACTN3 and ACE gene expression in CrossFit athletes for 12 weeks.<h4>Methods</h4>the studies included 18 athletes from the Rx category, where ACTN3 (RR, RX, XX) and ACE (II, ID, DD) characterization of genotypes and tests of maximum strength (NSCA), power (T-Force), and aerobic endurance (Course Navette) were performed. The technique used was the reverse transcription-quantitative PCR real-time polymerase chain reaction (RT-qPCR) for the relative expression analysiInternational journal of environmental research and public health4404https://www.ebi.ac.uk/biostudies/studies/S-EPMC10001917biostudies-literaturePrevalence of Polymorphism and Post-Training Expression of ACTN3 (R/X) and ACE (I/D) Genes in CrossFit Athletes.PMC10001917Cervantes Hernandez NPena-Vazquez OGuereca-Arvizuo JEnriquez-Del Castillo LAGonzalez-Chavez SAPacheco-Tena CCandia Lujan RCarrasco Legleu CEfalsePrevalence of Polymorphism and Post-Training Expression of ACTN3 (R/X) and ACE (I/D) Genes in CrossFit Athletes.<h4>Background</h4>CrossFit is known as a functional fitness training high-intensity exercise to improve physical performance. The most studied polymorphisms are the ACTN3 R577X gene, known for speed, power, and strength, and ACE I/D, related to endurance and strength. The present investigation analyzed the effects of training on ACTN3 and ACE gene expression in CrossFit athletes for 12 weeks.<h4>Methods</h4>the studies included 18 athletes from the Rx category, where ACTN3 (RR, RX, XX) and ACE (II, ID, DD) characterization of genotypes and tests of maximum strength (NSCA), power (T-Force), and aerobic endurance (Course Navette) were performed. The technique used was the reverse transcription-quantitative PCR real-time polymerase chain reaction (RT-qPCR) for the relative expression analysi2023-01-01T00:00:00Z2023 Mar2025-04-26T14:05:42.114Z2024-11-09T23:43:45.214ZS-EPMC100019173690141310.3390/ijerph20054404