{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sen P"],"funding":["German Center for Cardiovascular Research","Friedrich Bauer Foundation","the Dutch CardioVascular Alliance: An initiative with support of the Dutch Heart Foundation","European Union","German Centre for Cardiovascular Research","European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement"],"pagination":["4870"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10003314"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(5)"],"pubmed_abstract":["Pulmonary vein stenosis (PVS) causes a rare type of pulmonary hypertension (PH) by impacting the flow and pressure within the pulmonary vasculature, resulting in endothelial dysfunction and metabolic changes. A prudent line of treatment in this type of PH would be targeted therapy to relieve the pressure and reverse the flow-related changes. We used a swine model in order to mimic PH after PVS using pulmonary vein banding (PVB) of the lower lobes for 12 weeks to mimic the hemodynamic profile associated with PH and investigated the molecular alterations that provide an impetus for the development of PH. Our current study aimed to employ unbiased proteomic and metabolomic analyses on both the upper and lower lobes of the swine lung to identify regions with metabolic alterations. We detected "],"journal":["International journal of molecular sciences"],"pubmed_title":["Proteomics- and Metabolomics-Based Analysis of Metabolic Changes in a Swine Model of Pulmonary Hypertension."],"pmcid":["PMC10003314"],"funding_grant_id":["28/21","Marie Skłodowska -Curie Grant Agreement No. 812660 (DohART -NET)","Reg Nr- 28/21","DZHK81Z0600207","2020B008 RECONNEXT","812660"],"pubmed_authors":["Merkus D","Flenkenthaler F","Frohlich T","Meng C","Gigl M","Van de Kamp E","Tian S","Shashikadze B","Sen P"],"additional_accession":[]},"is_claimable":false,"name":"Proteomics- and Metabolomics-Based Analysis of Metabolic Changes in a Swine Model of Pulmonary Hypertension.","description":"Pulmonary vein stenosis (PVS) causes a rare type of pulmonary hypertension (PH) by impacting the flow and pressure within the pulmonary vasculature, resulting in endothelial dysfunction and metabolic changes. A prudent line of treatment in this type of PH would be targeted therapy to relieve the pressure and reverse the flow-related changes. We used a swine model in order to mimic PH after PVS using pulmonary vein banding (PVB) of the lower lobes for 12 weeks to mimic the hemodynamic profile associated with PH and investigated the molecular alterations that provide an impetus for the development of PH. Our current study aimed to employ unbiased proteomic and metabolomic analyses on both the upper and lower lobes of the swine lung to identify regions with metabolic alterations. We detected ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-04-08T14:20:12.411Z","creation":"2025-02-19T02:38:24.241Z"},"accession":"S-EPMC10003314","cross_references":{"pubmed":["36902298"],"doi":["10.3390/ijms24054870"]}}