{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Ren B"],"pubmed_abstract":["<h4>Background</h4>Neutrophil extracellular traps (NETs) can enhance the metastasis of non-small cell lung cancer (NSCLC). As biomarkers of tumor metastasis, metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) together with NETs are essential to endothelial-to-mesenchymal transition (EMT). We hypothesized that intravenous infusion of lidocaine and dexmedetomidine could reduce the production of NETs and biomarkers of tumor metastasis after video-assisted thoracic surgery (VATS) in NSCLC patients.<h4>Method</h4>The trial included 132 NSCLC patients undergoing VATS. The patients were equally randomized to a placebo group (Group C), a lidocaine group (Group L, intravenous lidocaine 8 mg/kg/h for 15 minutes before anesthesia, 2 mg/kg/h during surgery, and 1 mg/kg/h until 24 "],"journal":["Frontiers in oncology"],"pagination":["1101449"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10003334"],"repository":["biostudies-literature"],"pubmed_title":["Perioperative lidocaine and dexmedetomidine intravenous infusion reduce the serum levels of NETs and biomarkers of tumor metastasis in lung cancer patients: A prospective, single-center, double-blinded, randomized clinical trial."],"pmcid":["PMC10003334"],"pubmed_authors":["Zheng H","Zhang J","Wang R","Chen W","Cheng M","Liu C","Liu T","Wang Z","Ren B","Song J","Zhuang J"],"additional_accession":[]},"is_claimable":false,"name":"Perioperative lidocaine and dexmedetomidine intravenous infusion reduce the serum levels of NETs and biomarkers of tumor metastasis in lung cancer patients: A prospective, single-center, double-blinded, randomized clinical trial.","description":"<h4>Background</h4>Neutrophil extracellular traps (NETs) can enhance the metastasis of non-small cell lung cancer (NSCLC). As biomarkers of tumor metastasis, metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) together with NETs are essential to endothelial-to-mesenchymal transition (EMT). We hypothesized that intravenous infusion of lidocaine and dexmedetomidine could reduce the production of NETs and biomarkers of tumor metastasis after video-assisted thoracic surgery (VATS) in NSCLC patients.<h4>Method</h4>The trial included 132 NSCLC patients undergoing VATS. The patients were equally randomized to a placebo group (Group C), a lidocaine group (Group L, intravenous lidocaine 8 mg/kg/h for 15 minutes before anesthesia, 2 mg/kg/h during surgery, and 1 mg/kg/h until 24 ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-06-03T16:49:04.518Z","creation":"2025-04-19T05:35:29.285Z"},"accession":"S-EPMC10003334","cross_references":{"pubmed":["36910600"],"doi":["10.3389/fonc.2023.1101449"]}}