{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kotlarczyk AM"],"funding":["National Science Center"],"pagination":["4771"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10003591"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(5)"],"pubmed_abstract":["Reproductive and condition parameters' dependency on immune status in seasonally reproducing ruminants such as red deer have not been outlined to date. We determined T and B blood lymphocytes; the concentration of IgG, cAMP, haptoglobulin, and 6-keto-PGF1α in blood plasma; and the mRNA and protein expression of PG endoperoxide synthase 2, 5-lipoxygenase, PGE2 synthase (PGES), PGF2α synthase (PGFS), PGI2 synthase (PGIS), leukotriene (LT)A4 hydrolase, and LTC4 synthase (LTC4S) in the uterine endo- and myometrium, on the 4th (N = 7) and 13th (N = 8) days of the estrous cycle, in anestrus (N = 6) and pregnancy (N = 8) in hinds. An increase in CD4+ T regulatory lymphocyte percentage during the estrous cycle and anestrus compared with pregnancy was recorded; the opposite effect was observed for "],"journal":["International journal of molecular sciences"],"pubmed_title":["How Is Arachidonic Acid Metabolism in the Uterus Connected with the Immune Status of Red Deer Females (<i>Cervus elaphus</i> L.) in Different Reproductive Stages?"],"pmcid":["PMC10003591"],"funding_grant_id":["OPUS 2017/25/B/NZ9/02544"],"pubmed_authors":["Witkowska-Pilaszewicz O","Kotlarczyk AM","Kaczmarczyk J","Korzekwa AJ","Kotula-Balak M"],"additional_accession":[]},"is_claimable":false,"name":"How Is Arachidonic Acid Metabolism in the Uterus Connected with the Immune Status of Red Deer Females (<i>Cervus elaphus</i> L.) in Different Reproductive Stages?","description":"Reproductive and condition parameters' dependency on immune status in seasonally reproducing ruminants such as red deer have not been outlined to date. We determined T and B blood lymphocytes; the concentration of IgG, cAMP, haptoglobulin, and 6-keto-PGF1α in blood plasma; and the mRNA and protein expression of PG endoperoxide synthase 2, 5-lipoxygenase, PGE2 synthase (PGES), PGF2α synthase (PGFS), PGI2 synthase (PGIS), leukotriene (LT)A4 hydrolase, and LTC4 synthase (LTC4S) in the uterine endo- and myometrium, on the 4th (N = 7) and 13th (N = 8) days of the estrous cycle, in anestrus (N = 6) and pregnancy (N = 8) in hinds. An increase in CD4+ T regulatory lymphocyte percentage during the estrous cycle and anestrus compared with pregnancy was recorded; the opposite effect was observed for ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T03:42:09.107Z","creation":"2025-04-04T03:42:09.107Z"},"accession":"S-EPMC10003591","cross_references":{"pubmed":["36902199"],"doi":["10.3390/ijms24054771"]}}