biostudies-literatureKotlarczyk AMNational Science Center4771https://www.ebi.ac.uk/biostudies/studies/S-EPMC10003591biostudies-literatureUnknown24(5)Reproductive and condition parameters' dependency on immune status in seasonally reproducing ruminants such as red deer have not been outlined to date. We determined T and B blood lymphocytes; the concentration of IgG, cAMP, haptoglobulin, and 6-keto-PGF1α in blood plasma; and the mRNA and protein expression of PG endoperoxide synthase 2, 5-lipoxygenase, PGE2 synthase (PGES), PGF2α synthase (PGFS), PGI2 synthase (PGIS), leukotriene (LT)A4 hydrolase, and LTC4 synthase (LTC4S) in the uterine endo- and myometrium, on the 4th (N = 7) and 13th (N = 8) days of the estrous cycle, in anestrus (N = 6) and pregnancy (N = 8) in hinds. An increase in CD4+ T regulatory lymphocyte percentage during the estrous cycle and anestrus compared with pregnancy was recorded; the opposite effect was observed for International journal of molecular sciencesHow Is Arachidonic Acid Metabolism in the Uterus Connected with the Immune Status of Red Deer Females (<i>Cervus elaphus</i> L.) in Different Reproductive Stages?PMC10003591OPUS 2017/25/B/NZ9/02544Witkowska-Pilaszewicz OKotlarczyk AMKaczmarczyk JKorzekwa AJKotula-Balak MfalseHow Is Arachidonic Acid Metabolism in the Uterus Connected with the Immune Status of Red Deer Females (<i>Cervus elaphus</i> L.) in Different Reproductive Stages?Reproductive and condition parameters' dependency on immune status in seasonally reproducing ruminants such as red deer have not been outlined to date. We determined T and B blood lymphocytes; the concentration of IgG, cAMP, haptoglobulin, and 6-keto-PGF1α in blood plasma; and the mRNA and protein expression of PG endoperoxide synthase 2, 5-lipoxygenase, PGE2 synthase (PGES), PGF2α synthase (PGFS), PGI2 synthase (PGIS), leukotriene (LT)A4 hydrolase, and LTC4 synthase (LTC4S) in the uterine endo- and myometrium, on the 4th (N = 7) and 13th (N = 8) days of the estrous cycle, in anestrus (N = 6) and pregnancy (N = 8) in hinds. An increase in CD4+ T regulatory lymphocyte percentage during the estrous cycle and anestrus compared with pregnancy was recorded; the opposite effect was observed for 2023-01-01T00:00:00Z2023 Mar2025-04-04T03:42:09.107Z2025-04-04T03:42:09.107ZS-EPMC100035913690219910.3390/ijms24054771