{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Stoliaroff-Pepin A"],"funding":["Bundesministerium für Gesundheit","Robert Koch-Institut"],"pubmed_abstract":["<h4>Purpose</h4>COViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave.<h4>Methods</h4>We analyzed data from 276 cases with COVID-19 and 494 control patients recruited in 13 hospitals from 1 December 2021 to 5 September 2022. We calculated crude and confounder-adjusted VE estimates.<h4>Results</h4>21% of cases (57/276) were not vaccinated, compared to 5% of controls (26/494; p < 0.001). Confounder-adjusted VE against COVID-19-caused hospitalization was 55.4% (95% CI: 12-78%), 81.5% (95% CI: 68-90%) and 95.6% (95%CI: 88-99%) after two, three and four vaccin"],"journal":["Infection"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10009838"],"repository":["biostudies-literature"],"pubmed_title":["Vaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: results from the COViK study."],"pmcid":["PMC10009838"],"pubmed_authors":["Grossegesse M","Schuhlen H","Huster D","Peine C","Hofmann N","Glaser S","Lock G","Herath T","Nitsche A","Meyer T","Isner C","Reichardt A","Lachmann J","Werel L","Stoliaroff-Pepin A","Schaade L","Dorner BG","Kohl C","Treindl F","Hellenbrand W","Harder T","Hein S","Brinkmann A","Hildt E","Grunewald T","Michel J","Wichmann O","Perriat D","Dorre A","Stern D","Ghouzi A","Rinner T","Janneck M","Peric A"],"additional_accession":[]},"is_claimable":false,"name":"Vaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: results from the COViK study.","description":"<h4>Purpose</h4>COViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave.<h4>Methods</h4>We analyzed data from 276 cases with COVID-19 and 494 control patients recruited in 13 hospitals from 1 December 2021 to 5 September 2022. We calculated crude and confounder-adjusted VE estimates.<h4>Results</h4>21% of cases (57/276) were not vaccinated, compared to 5% of controls (26/494; p < 0.001). Confounder-adjusted VE against COVID-19-caused hospitalization was 55.4% (95% CI: 12-78%), 81.5% (95% CI: 68-90%) and 95.6% (95%CI: 88-99%) after two, three and four vaccin","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-05-29T19:45:22.845Z","creation":"2025-04-05T13:32:29.122Z"},"accession":"S-EPMC10009838","cross_references":{"pubmed":["36913112"],"doi":["10.1007/s15010-023-02012-z"]}}