biostudies-literatureUnknownStoliaroff-Pepin ABundesministerium für GesundheitRobert Koch-Institut<h4>Purpose</h4>COViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave.<h4>Methods</h4>We analyzed data from 276 cases with COVID-19 and 494 control patients recruited in 13 hospitals from 1 December 2021 to 5 September 2022. We calculated crude and confounder-adjusted VE estimates.<h4>Results</h4>21% of cases (57/276) were not vaccinated, compared to 5% of controls (26/494; p < 0.001). Confounder-adjusted VE against COVID-19-caused hospitalization was 55.4% (95% CI: 12-78%), 81.5% (95% CI: 68-90%) and 95.6% (95%CI: 88-99%) after two, three and four vaccinInfectionhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC10009838biostudies-literatureVaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: results from the COViK study.PMC10009838Grossegesse MSchuhlen HHuster DPeine CHofmann NGlaser SLock GHerath TNitsche AMeyer TIsner CReichardt ALachmann JWerel LStoliaroff-Pepin ASchaade LDorner BGKohl CTreindl FHellenbrand WHarder THein SBrinkmann AHildt EGrunewald TMichel JWichmann OPerriat DDorre AStern DGhouzi ARinner TJanneck MPeric AfalseVaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: results from the COViK study.<h4>Purpose</h4>COViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave.<h4>Methods</h4>We analyzed data from 276 cases with COVID-19 and 494 control patients recruited in 13 hospitals from 1 December 2021 to 5 September 2022. We calculated crude and confounder-adjusted VE estimates.<h4>Results</h4>21% of cases (57/276) were not vaccinated, compared to 5% of controls (26/494; p < 0.001). Confounder-adjusted VE against COVID-19-caused hospitalization was 55.4% (95% CI: 12-78%), 81.5% (95% CI: 68-90%) and 95.6% (95%CI: 88-99%) after two, three and four vaccin2023-01-01T00:00:00Z2023 Mar2025-05-29T19:45:22.845Z2025-04-05T13:32:29.122ZS-EPMC100098383691311210.1007/s15010-023-02012-z