{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Punzalan FER"],"funding":["Philippine Council for Health Research and Development"],"pubmed_abstract":["Purpose
This study was performed to determine the clinical biomarkers and cytokines that may be associated with disease progression and in-hospital mortality in a cohort of hospitalized patients with RT-PCR confirmed moderate to severe COVID-19 infection from October 2020 to September 2021, during the first wave of COVID-19 pandemic before the advent of vaccination.Patients and methods
Clinical profile was obtained from the medical records. Laboratory parameters (complete blood count [CBC], albumin, LDH, CRP, ferritin, D-dimer, and procalcitonin) and serum concentrations of cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18, IFN-γ, IP-10, TNF-α) were measured on Days 0-3, 4-10, 11-14 and beyond Day 14 from the onset of illness. Regression analysis was done to determine "],"journal":["Frontiers in immunology"],"pagination":["1123497"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10011458"],"repository":["biostudies-literature"],"pubmed_title":["Utility of laboratory and immune biomarkers in predicting disease progression and mortality among patients with moderate to severe COVID-19 disease at a Philippine tertiary hospital."],"pmcid":["PMC10011458"],"pubmed_authors":["Mondragon AV","Albay AB","Mercado MEP","Avenilla KC","de Paz-Silava SLM","Tan JJE","Alejandria MM","Aherrera JAM","David-Wang AS","Lintao RCV","Tantengco OAG","Poblete JB","Punzalan FER","Malundo AFG","Quebral EPB","Uy MNAR","Dela Rosa JGL"],"additional_accession":[]},"is_claimable":false,"name":"Utility of laboratory and immune biomarkers in predicting disease progression and mortality among patients with moderate to severe COVID-19 disease at a Philippine tertiary hospital.","description":"Purpose
This study was performed to determine the clinical biomarkers and cytokines that may be associated with disease progression and in-hospital mortality in a cohort of hospitalized patients with RT-PCR confirmed moderate to severe COVID-19 infection from October 2020 to September 2021, during the first wave of COVID-19 pandemic before the advent of vaccination.Patients and methods
Clinical profile was obtained from the medical records. Laboratory parameters (complete blood count [CBC], albumin, LDH, CRP, ferritin, D-dimer, and procalcitonin) and serum concentrations of cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18, IFN-γ, IP-10, TNF-α) were measured on Days 0-3, 4-10, 11-14 and beyond Day 14 from the onset of illness. Regression analysis was done to determine ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-06-03T17:12:47.784Z","creation":"2025-04-21T15:06:14.534Z"},"accession":"S-EPMC10011458","cross_references":{"pubmed":["36926338"],"doi":["10.3389/fimmu.2023.1123497"]}}