biostudies-literatureUnknown14Punzalan FERPhilippine Council for Health Research and Development<h4>Purpose</h4>This study was performed to determine the clinical biomarkers and cytokines that may be associated with disease progression and in-hospital mortality in a cohort of hospitalized patients with RT-PCR confirmed moderate to severe COVID-19 infection from October 2020 to September 2021, during the first wave of COVID-19 pandemic before the advent of vaccination.<h4>Patients and methods</h4>Clinical profile was obtained from the medical records. Laboratory parameters (complete blood count [CBC], albumin, LDH, CRP, ferritin, D-dimer, and procalcitonin) and serum concentrations of cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18, IFN-γ, IP-10, TNF-α) were measured on Days 0-3, 4-10, 11-14 and beyond Day 14 from the onset of illness. Regression analysis was done to determine Frontiers in immunology1123497https://www.ebi.ac.uk/biostudies/studies/S-EPMC10011458biostudies-literatureUtility of laboratory and immune biomarkers in predicting disease progression and mortality among patients with moderate to severe COVID-19 disease at a Philippine tertiary hospital.PMC10011458Mondragon AVAlbay ABMercado MEPAvenilla KCde Paz-Silava SLMTan JJEAlejandria MMAherrera JAMDavid-Wang ASLintao RCVTantengco OAGPoblete JBPunzalan FERMalundo AFGQuebral EPBUy MNARDela Rosa JGLfalseUtility of laboratory and immune biomarkers in predicting disease progression and mortality among patients with moderate to severe COVID-19 disease at a Philippine tertiary hospital.<h4>Purpose</h4>This study was performed to determine the clinical biomarkers and cytokines that may be associated with disease progression and in-hospital mortality in a cohort of hospitalized patients with RT-PCR confirmed moderate to severe COVID-19 infection from October 2020 to September 2021, during the first wave of COVID-19 pandemic before the advent of vaccination.<h4>Patients and methods</h4>Clinical profile was obtained from the medical records. Laboratory parameters (complete blood count [CBC], albumin, LDH, CRP, ferritin, D-dimer, and procalcitonin) and serum concentrations of cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18, IFN-γ, IP-10, TNF-α) were measured on Days 0-3, 4-10, 11-14 and beyond Day 14 from the onset of illness. Regression analysis was done to determine 2023-01-01T00:00:00Z20232026-06-03T17:12:47.784Z2025-04-21T15:06:14.534ZS-EPMC100114583692633810.3389/fimmu.2023.1123497