{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["120(10)"],"submitter":["Jiang H"],"pubmed_abstract":["The association of decreased fecundity with insecticide resistance and the negative sublethal effects of insecticides on insect reproduction indicates the typical trade-off between two highly energy-demanding processes, detoxification and reproduction. However, the underlying mechanisms are poorly understood. The energy sensor adenosine monophosphate-activated protein kinase (AMPK) and the transcription factor Cap \"n\" collar isoform C (CncC) are important regulators of energy metabolism and xenobiotic response, respectively. In this study, using the beetle <i>Tribolium castaneum</i> as a model organism, we found that deltamethrin-induced oxidative stress activated AMPK, which promoted the nuclear translocation of CncC through its phosphorylation. The CncC not only acts as a transcription a"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["e2214038120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10013871"],"repository":["biostudies-literature"],"pubmed_title":["The pleiotropic AMPK-CncC signaling pathway regulates the trade-off between detoxification and reproduction."],"pmcid":["PMC10013871"],"pubmed_authors":["Zheng Y","Park Y","Jiang H","Ge H","Zhang N","Wei J","Qian K","Wang J","Meng X","Reddy Palli S"],"additional_accession":[]},"is_claimable":false,"name":"The pleiotropic AMPK-CncC signaling pathway regulates the trade-off between detoxification and reproduction.","description":"The association of decreased fecundity with insecticide resistance and the negative sublethal effects of insecticides on insect reproduction indicates the typical trade-off between two highly energy-demanding processes, detoxification and reproduction. However, the underlying mechanisms are poorly understood. The energy sensor adenosine monophosphate-activated protein kinase (AMPK) and the transcription factor Cap \"n\" collar isoform C (CncC) are important regulators of energy metabolism and xenobiotic response, respectively. In this study, using the beetle <i>Tribolium castaneum</i> as a model organism, we found that deltamethrin-induced oxidative stress activated AMPK, which promoted the nuclear translocation of CncC through its phosphorylation. The CncC not only acts as a transcription a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T20:07:15.543Z","creation":"2025-04-04T20:07:15.543Z"},"accession":"S-EPMC10013871","cross_references":{"pubmed":["36853946"],"doi":["10.1073/pnas.2214038120"]}}