{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pastor-Fernandez A"],"funding":["China Shipbuilding Industry","Instituto de Salud Carlos III","Ministerio de Ciencia e Innovación"],"pagination":["e13771"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10014049"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(3)"],"pubmed_abstract":["The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro-inflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) significantly reduced SARS-CoV-2-related mortality, delayed its onset, and reduced the number of other clinical symptoms. The increase in senescent markers that we detected in the lungs in response to SARS"],"journal":["Aging cell"],"pubmed_title":["Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice."],"pmcid":["PMC10014049"],"funding_grant_id":["PID2020‐113888RB‐I00","SAF2017‐85766‐R","CSIC‐COV19‐014","COV20‐00755","PID2020‐114077RB‐I00","COV20‐00792","RYC‐2017‐22335"],"pubmed_authors":["Del Moral-Salmoral J","Gonzalez-Aseguinolaza G","Smerdou C","Merino J","de Avila AI","Bertos AR","Girones N","Olague C","Fresno M","Sierra-Ramirez A","Fernandez-Marcos PJ","Rodriguez MA","Pastor-Fernandez A","von Kobbe C","Villares R","Bustos M"],"additional_accession":[]},"is_claimable":false,"name":"Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice.","description":"The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro-inflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) significantly reduced SARS-CoV-2-related mortality, delayed its onset, and reduced the number of other clinical symptoms. The increase in senescent markers that we detected in the lungs in response to SARS","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-06-28T03:04:51.025Z","creation":"2025-04-07T12:35:48.205Z"},"accession":"S-EPMC10014049","cross_references":{"pubmed":["36704839"],"doi":["10.1111/acel.13771"]}}