biostudies-literaturePastor-Fernandez AChina Shipbuilding IndustryInstituto de Salud Carlos IIIMinisterio de Ciencia e Innovacióne13771https://www.ebi.ac.uk/biostudies/studies/S-EPMC10014049biostudies-literatureUnknown22(3)The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro-inflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) significantly reduced SARS-CoV-2-related mortality, delayed its onset, and reduced the number of other clinical symptoms. The increase in senescent markers that we detected in the lungs in response to SARSAging cellTreatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice.PMC10014049PID2020‐113888RB‐I00SAF2017‐85766‐RCSIC‐COV19‐014COV20‐00755PID2020‐114077RB‐I00COV20‐00792RYC‐2017‐22335Del Moral-Salmoral JGonzalez-Aseguinolaza GSmerdou CMerino Jde Avila AIBertos ARGirones NOlague CFresno MSierra-Ramirez AFernandez-Marcos PJRodriguez MAPastor-Fernandez Avon Kobbe CVillares RBustos MfalseTreatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice.The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro-inflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) significantly reduced SARS-CoV-2-related mortality, delayed its onset, and reduced the number of other clinical symptoms. The increase in senescent markers that we detected in the lungs in response to SARS2023-01-01T00:00:00Z2023 Mar2025-06-28T03:04:51.025Z2025-04-07T12:35:48.205ZS-EPMC100140493670483910.1111/acel.13771