{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kanel P"],"funding":["Foundation for the National Institutes of Health","RRD VA","National Parkinson Foundation","NINDS NIH HHS","U.S. Department of Veterans Affairs","NIH HHS","Michael J. Fox Foundation for Parkinson&apos;s Research"],"pagination":["1469-1479"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10017092"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["129(12)"],"pubmed_abstract":["Prior studies indicate more severe brainstem cholinergic deficits in Progressive Supranuclear Palsy (PSP) compared to Parkinson's disease (PD), but the extent and topography of subcortical deficits remains poorly understood. The objective of this study is to investigate differential cholinergic systems changes in progressive supranuclear palsy (PSP, n = 8) versus Parkinson's disease (PD, n = 107) and older controls (n = 19) using vesicular acetylcholine transporter [<sup>18</sup>F]-fluoroethoxybenzovesamicol (FEOBV) positron emission tomography (PET). A whole-brain voxel-based PET analysis using Statistical Parametric Mapping (SPM) software (SPM12) for inter-group comparisons using parametric [<sup>18</sup>F]-FEOBV DVR images. Voxel-based analyses showed lower FEOBV binding in the tectum, "],"journal":["Journal of neural transmission (Vienna, Austria : 1996)"],"pubmed_title":["Differential cholinergic systems' changes in progressive supranuclear palsy versus Parkinson's disease: an exploratory analysis."],"pmcid":["PMC10017092"],"funding_grant_id":["P01 NS015655","I01 RX001631","P50 NS091856","RO1 NS070856","R01 NS070856","P50 NS123067"],"pubmed_authors":["Koeppe RA","Scott PJH","Frey KA","Kanel P","Bohnen NI","Roytman S","Spears CC","Albin RL"],"additional_accession":[]},"is_claimable":false,"name":"Differential cholinergic systems' changes in progressive supranuclear palsy versus Parkinson's disease: an exploratory analysis.","description":"Prior studies indicate more severe brainstem cholinergic deficits in Progressive Supranuclear Palsy (PSP) compared to Parkinson's disease (PD), but the extent and topography of subcortical deficits remains poorly understood. The objective of this study is to investigate differential cholinergic systems changes in progressive supranuclear palsy (PSP, n = 8) versus Parkinson's disease (PD, n = 107) and older controls (n = 19) using vesicular acetylcholine transporter [<sup>18</sup>F]-fluoroethoxybenzovesamicol (FEOBV) positron emission tomography (PET). A whole-brain voxel-based PET analysis using Statistical Parametric Mapping (SPM) software (SPM12) for inter-group comparisons using parametric [<sup>18</sup>F]-FEOBV DVR images. Voxel-based analyses showed lower FEOBV binding in the tectum, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-21T23:46:07.692Z","creation":"2025-04-05T19:14:53.533Z"},"accession":"S-EPMC10017092","cross_references":{"pubmed":["36222971"],"doi":["10.1007/s00702-022-02547-9"]}}