biostudies-literatureBian XNational Institute of Allergy and Infectious DiseasesNIAID NIH HHS114171https://www.ebi.ac.uk/biostudies/studies/S-EPMC10019944biostudies-literatureUnknown183Antimicrobial resistance is a major global health challenge. As few new efficacious antibiotics will become available in the near future, peptide antibiotics continue to be major therapeutic options for treating infections caused by multidrug-resistant pathogens. Rational use of antibiotics requires optimisation of the pharmacokinetics and pharmacodynamics for the treatment of different types of infections. Toxicodynamics must also be considered to improve the safety of antibiotic use and, where appropriate, to guide therapeutic drug monitoring. This review focuses on the pharmacokinetics/pharmacodynamics/toxicodynamics of peptide antibiotics against multidrug-resistant Gram-negative and Gram-positive pathogens. Optimising antibiotic exposure at the infection site is essential for improvinAdvanced drug delivery reviewsPharmacokinetics and pharmacodynamics of peptide antibiotics.PMC10019944R01 AI146160R01 AI132681Chan HKFeng MLi JZhang JBian XQu XNang SCTony Zhou QBergen PJfalsePharmacokinetics and pharmacodynamics of peptide antibiotics.Antimicrobial resistance is a major global health challenge. As few new efficacious antibiotics will become available in the near future, peptide antibiotics continue to be major therapeutic options for treating infections caused by multidrug-resistant pathogens. Rational use of antibiotics requires optimisation of the pharmacokinetics and pharmacodynamics for the treatment of different types of infections. Toxicodynamics must also be considered to improve the safety of antibiotic use and, where appropriate, to guide therapeutic drug monitoring. This review focuses on the pharmacokinetics/pharmacodynamics/toxicodynamics of peptide antibiotics against multidrug-resistant Gram-negative and Gram-positive pathogens. Optimising antibiotic exposure at the infection site is essential for improvin2022-01-01T00:00:00Z2022 Apr2025-04-26T13:09:56.523Z2025-04-06T14:11:00.228ZS-EPMC100199443518926410.1016/j.addr.2022.114171