biostudies-literatureUnknown38(3)Arthursson H<h4>Background</h4>Rewarming on cardiopulmonary bypass (CPB) is associated with increased metabolic demands; however, it remains unclear whether cerebral autoregulation is affected during this phase. This RCT aims to describe the effects of 20% supranormal, compared to normal CPB flow, on monitoring signs of inadequate perfusion, oxygenation, and disturbed cerebral autoregulation, during the rewarming phase of CPB.<h4>Method</h4>Thirty two patients scheduled for coronary artery bypass grafting were allocated to a Control group (<i>n</i> = 16) receiving a CPB pump flow corresponding to preoperatively measured cardiac output, and an Intervention group (<i>n</i> = 16) receiving the corresponding CPB pump flow increased by 20% during rewarming. Cerebral Oximetry Index (COx) was calculated withPerfusion523-529https://www.ebi.ac.uk/biostudies/studies/S-EPMC10026164biostudies-literatureCerebral oxygenation and autoregulation during rewarming on cardiopulmonary bypass.PMC10026164Lennmyr FArthursson HTovedal TKjellberg GfalseCerebral oxygenation and autoregulation during rewarming on cardiopulmonary bypass.<h4>Background</h4>Rewarming on cardiopulmonary bypass (CPB) is associated with increased metabolic demands; however, it remains unclear whether cerebral autoregulation is affected during this phase. This RCT aims to describe the effects of 20% supranormal, compared to normal CPB flow, on monitoring signs of inadequate perfusion, oxygenation, and disturbed cerebral autoregulation, during the rewarming phase of CPB.<h4>Method</h4>Thirty two patients scheduled for coronary artery bypass grafting were allocated to a Control group (<i>n</i> = 16) receiving a CPB pump flow corresponding to preoperatively measured cardiac output, and an Intervention group (<i>n</i> = 16) receiving the corresponding CPB pump flow increased by 20% during rewarming. Cerebral Oximetry Index (COx) was calculated with2023-01-01T00:00:00Z2023 Apr2025-04-04T08:40:07.101Z2025-04-04T08:40:07.101ZS-EPMC100261643503894810.1177/02676591211064961