{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Oroszi T"],"funding":["ZonMW, Deltaplan Dementia and Alzheimer Nederland and Brain Foundation","Hungarian University of Sports Science","ZonMw"],"pagination":["5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10026461"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["Background
Alzheimer's disease (AD) is the core cause of dementia in elderly populations. One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP-pathology) associated with glial-mediated neuroinflammation. Whole-Body Vibration (WBV) is a passive form of exercise, but its effects on AD pathology are still unknown.Methods
Five months old male J20 mice (n = 26) and their wild type (WT) littermates (n = 24) were used to investigate the effect of WBV on amyloid pathology and the healthy brain. Both J20 and WT mice underwent WBV on a vibration platform or pseudo vibration treatment. The vibration intervention consisted of 2 WBV sessions of 10 min per day, five days per week for five consecutive weeks. After five weeks of WBV, the balance beam test wa"],"journal":["Behavioral and brain functions : BBF"],"pubmed_title":["Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load."],"pmcid":["PMC10026461"],"funding_grant_id":["733050303"],"pubmed_authors":["Oroszi T","Geerts E","van der Zee EA","van Heuvelen MJG","Rajadhyaksha R","Nyakas C"],"additional_accession":[]},"is_claimable":false,"name":"Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load.","description":"Background
Alzheimer's disease (AD) is the core cause of dementia in elderly populations. One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP-pathology) associated with glial-mediated neuroinflammation. Whole-Body Vibration (WBV) is a passive form of exercise, but its effects on AD pathology are still unknown.Methods
Five months old male J20 mice (n = 26) and their wild type (WT) littermates (n = 24) were used to investigate the effect of WBV on amyloid pathology and the healthy brain. Both J20 and WT mice underwent WBV on a vibration platform or pseudo vibration treatment. The vibration intervention consisted of 2 WBV sessions of 10 min per day, five days per week for five consecutive weeks. After five weeks of WBV, the balance beam test wa","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-19T20:44:06.283Z","creation":"2025-04-19T20:44:06.283Z"},"accession":"S-EPMC10026461","cross_references":{"pubmed":["36941713"],"doi":["10.1186/s12993-023-00208-9"]}}