biostudies-literatureOroszi TZonMW, Deltaplan Dementia and Alzheimer Nederland and Brain FoundationHungarian University of Sports ScienceZonMw5https://www.ebi.ac.uk/biostudies/studies/S-EPMC10026461biostudies-literatureUnknown19(1)<h4>Background</h4>Alzheimer's disease (AD) is the core cause of dementia in elderly populations. One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP-pathology) associated with glial-mediated neuroinflammation. Whole-Body Vibration (WBV) is a passive form of exercise, but its effects on AD pathology are still unknown.<h4>Methods</h4>Five months old male J20 mice (n = 26) and their wild type (WT) littermates (n = 24) were used to investigate the effect of WBV on amyloid pathology and the healthy brain. Both J20 and WT mice underwent WBV on a vibration platform or pseudo vibration treatment. The vibration intervention consisted of 2 WBV sessions of 10 min per day, five days per week for five consecutive weeks. After five weeks of WBV, the balance beam test waBehavioral and brain functions : BBFWhole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load.PMC10026461733050303Oroszi TGeerts Evan der Zee EAvan Heuvelen MJGRajadhyaksha RNyakas CfalseWhole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load.<h4>Background</h4>Alzheimer's disease (AD) is the core cause of dementia in elderly populations. One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP-pathology) associated with glial-mediated neuroinflammation. Whole-Body Vibration (WBV) is a passive form of exercise, but its effects on AD pathology are still unknown.<h4>Methods</h4>Five months old male J20 mice (n = 26) and their wild type (WT) littermates (n = 24) were used to investigate the effect of WBV on amyloid pathology and the healthy brain. Both J20 and WT mice underwent WBV on a vibration platform or pseudo vibration treatment. The vibration intervention consisted of 2 WBV sessions of 10 min per day, five days per week for five consecutive weeks. After five weeks of WBV, the balance beam test wa2023-01-01T00:00:00Z2023 Mar2025-04-19T20:44:06.283Z2025-04-19T20:44:06.283ZS-EPMC100264613694171310.1186/s12993-023-00208-9