biostudies-literatureUnknown26(3)Teeraananchai SCollaborative Initiative for Paediatric HIV Education and Research (CIPHER) grant programme by the International AIDS Society from 2018 to 2020<h4>Introduction</h4>The Thai National AIDS programme (NAP) treatment guidelines have recommended rapid antiretroviral therapy (ART) initiation, regardless of CD4 count since 2014. We assessed treatment outcomes among youth living with HIV (YLHIV), initiating first-line ART and assessed the association between virological failure (VF) and timing of ART initiation.<h4>Methods</h4>We retrospectively reviewed data for YLHIV aged 15-24 years, initiating non-nucleoside reverse transcriptase inhibitor-based ART from 2014 to 2019, through the NAP database. We classified the timing of ART into three groups based on duration from HIV-positive diagnosis or system registration to ART initiation: (1) <1 month (rapid ART); (2) 1-3 months (intermediate ART); and (3) >3 months (delayed ART). VF was definJournal of the International AIDS Societye26071https://www.ebi.ac.uk/biostudies/studies/S-EPMC10029993biostudies-literatureLong-term outcomes of rapid antiretroviral NNRTI-based initiation among Thai youth living with HIV: a national registry database study.PMC10029993Puthanakit TRuxrungtham KKhananuraksa PKerr SJTeeraananchai SfalseLong-term outcomes of rapid antiretroviral NNRTI-based initiation among Thai youth living with HIV: a national registry database study.<h4>Introduction</h4>The Thai National AIDS programme (NAP) treatment guidelines have recommended rapid antiretroviral therapy (ART) initiation, regardless of CD4 count since 2014. We assessed treatment outcomes among youth living with HIV (YLHIV), initiating first-line ART and assessed the association between virological failure (VF) and timing of ART initiation.<h4>Methods</h4>We retrospectively reviewed data for YLHIV aged 15-24 years, initiating non-nucleoside reverse transcriptase inhibitor-based ART from 2014 to 2019, through the NAP database. We classified the timing of ART into three groups based on duration from HIV-positive diagnosis or system registration to ART initiation: (1) <1 month (rapid ART); (2) 1-3 months (intermediate ART); and (3) >3 months (delayed ART). VF was defin2023-01-01T00:00:00Z2023 Mar2025-04-19T14:59:33.993Z2025-04-19T14:59:33.993ZS-EPMC100299933694372910.1002/jia2.26071