{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(3)"],"submitter":["Cattaneo A"],"pubmed_abstract":["<h4>Background</h4>One of the longest-standing treatments to prevent delayed cerebral infarction (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH) remains raising the blood pressure to a certain level of mean arterial pressure. This may require high doses of norepinephrine, which has been associated with severe end organ damage. With this study, we aimed to investigate the effects of norepinephrine on the incidence of DCI in a clinical setting.<h4>Methods</h4>We conducted a retrospective evaluation of patients with aSAH admitted to our institution between November 2018 and March 2021. Potential risk factors for DCI were analyzed and significant predictors were assessed by means of a logistic regression analysis to account for potential confounders.<h4>Results</h4>In this stu"],"journal":["PloS one"],"pagination":["e0283180"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10030022"],"repository":["biostudies-literature"],"pubmed_title":["Investigating the relationship between high-dose norepinephrine administration and the incidence of delayed cerebral infarction in patients with aneurysmal subarachnoid hemorrhage: A single-center retrospective evaluation."],"pmcid":["PMC10030022"],"pubmed_authors":["Westermaier T","Semmler F","Griessenauer CJ","Cattaneo A","Wipplinger C","Kunze E","Wipplinger TM","Stetter C","Beez A","Geske C","Weiland J","Ernestus RI"],"additional_accession":[]},"is_claimable":false,"name":"Investigating the relationship between high-dose norepinephrine administration and the incidence of delayed cerebral infarction in patients with aneurysmal subarachnoid hemorrhage: A single-center retrospective evaluation.","description":"<h4>Background</h4>One of the longest-standing treatments to prevent delayed cerebral infarction (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH) remains raising the blood pressure to a certain level of mean arterial pressure. This may require high doses of norepinephrine, which has been associated with severe end organ damage. With this study, we aimed to investigate the effects of norepinephrine on the incidence of DCI in a clinical setting.<h4>Methods</h4>We conducted a retrospective evaluation of patients with aSAH admitted to our institution between November 2018 and March 2021. Potential risk factors for DCI were analyzed and significant predictors were assessed by means of a logistic regression analysis to account for potential confounders.<h4>Results</h4>In this stu","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-19T15:00:47.492Z","creation":"2025-04-19T15:00:47.492Z"},"accession":"S-EPMC10030022","cross_references":{"pubmed":["36943859"],"doi":["10.1371/journal.pone.0283180"]}}