biostudies-literatureJohnson DBMelanoma Research FoundationNCI NIH HHS265https://www.ebi.ac.uk/biostudies/studies/S-EPMC10033295biostudies-literatureUnknown23(1)<h4>Introduction</h4>COVID-19 particularly impacted patients with co-morbid conditions, including cancer. Patients with melanoma have not been specifically studied in large numbers. Here, we sought to identify factors that associated with COVID-19 severity among patients with melanoma, particularly assessing outcomes of patients on active targeted or immune therapy.<h4>Methods</h4>Using the COVID-19 and Cancer Consortium (CCC19) registry, we identified 307 patients with melanoma diagnosed with COVID-19. We used multivariable models to assess demographic, cancer-related, and treatment-related factors associated with COVID-19 severity on a 6-level ordinal severity scale. We assessed whether treatment was associated with increased cardiac or pulmonary dysfunction among hospitalized patients aBMC cancerImpact of COVID-19 in patients on active melanoma therapy and with history of melanoma.PMC10033295K12 CA090625Bekaii-Saab TSJhawar SRReynolds KLMico VDemetri GDTejwani SO'Connor TEBalanchivadze NSchmidt ALBardia AWilliams CGoldsmith KJRock CDVan Loon SRiaz IBFecher LAZaren HAMavromatis BHFu JCLoRusso PEgan PCMonahan RSFazio AMisdary CFBilen MARevankar SGMasters TVilar-Compte DShah SAMatar SKhaki ARBoldt AAccordino MKAdvani PGSmits MNohria AXu WCastellano CAEnriquez KTFerrario CSchroeder BABoland GFreeman DALabaki CGill DMGriffiths EABlau EGRSLammers PEPanasci JLi ARamirez ADutra MSClement JMDeeken JFDuma NNelson HHWilliamson SPSueyoshi MHLyman GHWall SLatif TGupta SHsu EFarmakiotis DBatist GRavindranathan DMishra SJha AYoon JJHalabi SAlimohamed SIAtkins MBMandapakala CGulati SBerg SFahey CCAhluwalia MSNagaraj GRivera AVVinayak SKligerman SHuber KESachs ZBeeghly-Fadiel AAwosika JPhilip JBhatt PSSmith SJHausrath DYu PPAndermann TMStover DGGrivas PGulati APKwon DHDel Prete SABashir BKlein EJWagner MJFaller BBouganim NGadgeel SMElkrief ALemmon CARuiz-Garcia EWang LLCarducci TMZhou AYHsiao AGillaspie EAFiala MASchapira LDurbin EBMorgans AKSchwartz GKHennessy CCabebe ECLi XFriese CRReuben DYThomson CCSingh SRKTachiki LCroessmann SHayes-Lattin BBar MHConnors JMYeh ALow CAJensen CAddison DVan Allen EMFeldman LEJayaraj AGrover PVega-Luna KLustberg MBKasi AButt OLo KMSCOVID-19 and Cancer ConsortiumAkhtari MChoueiri TKSerrano OKGalsky MDLewis GCVenepalli NKMcNair CKharofa JZhang TAjmera AHwang CRhodes TDPolimera HVTopaloglu UOlszewski AJDailey MEKulkarni AAGantt GTucker MDMarcum MZamulko ORose SJSchweizer MTIngham MABernicker EHShah SLynch RCRosovsky RPZhang SReid SAKloecker GHuynh-Le MPWood WASharifi NPuc MNguyen RHPeddi PBrouha SSAhmad SAZubiri LDawsey SJJani CBakouny ZGlover MJWeinstein PLElias RSlosky DAMushtaq SCook EWulff-Burchfield EWise-Draper TReeves MEHoppenot CShafer DDesai ARiely GJWarner JLMahmood SZMiller WHShah MRBijjula RRPomerantz LDBhutani DWu JTEdwin NCKoshkin VSHalfdanarson TRBelenkaya RRubinstein SMAboulafiam DMZaman QUKarivedu VCheng AWise-Draper TMArvanitis PGeiger CLHoskins KFPasquinelli MJohnson DBHenderson JPVinh DCWotman MSaliby RMWeissman LBMenendez AGSmith KEGiordano AHafez NSolorzano CCHawley JEGoyal SRosen LRNemecek ERLogan BBCastillo DRGainor JFMashru SHLoggers ETHerbst RStockerl-Goldstein KELiu LCDoroshow DBMcWeeney SMcCollough BBLewis MAVieira KMcKay RRMariano MGMansoor AHViera KHershman DSmall EJBrown AJJabbour SKAlexander MChen JLChoi SSchwartz CNakasone ESGatti-Mays MECohen AMSohal DPSGraber JJAbbasi SHBowles DWJoshi MPalmer JDZon RLStratton JDavis EJRovito MAKnox NDzimitrowicz HWeissmann LBBorno HTNonato TKMoore JKWilliams NODaher AStratton CKhan HFrench BKhan MFlora DBLau ENizam APennell NAPuzanov IHeilman HfalseImpact of COVID-19 in patients on active melanoma therapy and with history of melanoma.<h4>Introduction</h4>COVID-19 particularly impacted patients with co-morbid conditions, including cancer. Patients with melanoma have not been specifically studied in large numbers. Here, we sought to identify factors that associated with COVID-19 severity among patients with melanoma, particularly assessing outcomes of patients on active targeted or immune therapy.<h4>Methods</h4>Using the COVID-19 and Cancer Consortium (CCC19) registry, we identified 307 patients with melanoma diagnosed with COVID-19. We used multivariable models to assess demographic, cancer-related, and treatment-related factors associated with COVID-19 severity on a 6-level ordinal severity scale. We assessed whether treatment was associated with increased cardiac or pulmonary dysfunction among hospitalized patients a2023-01-01T00:00:00Z2023 Mar2025-04-22T12:02:28.917Z2024-11-20T23:16:28.243ZS-EPMC100332953694941310.1186/s12885-023-10708-6