{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["199(4)"],"submitter":["Wolf J"],"funding":["Universitätsklinikum Freiburg"],"pubmed_abstract":["<h4>Background</h4>Radiotherapy can induce cardiac injury in left-sided breast cancer cases. Cardiac-sparing irradiation using the deep inspiration breath-hold (DIBH) technique can achieve substantial dose reduction to vulnerable cardiac substructures compared with free breathing (FB). This study evaluated the dosimetric differences between both techniques at a single institution.<h4>Methods</h4>From 2017 to 2019, 130 patients with left-sided breast cancer underwent breast-conserving surgery (BCS; n = 121, 93.1%) or mastectomy (ME; n = 9, 6.9%) along with axillary lymph node staging (n = 105, 80.8%), followed by adjuvant irradiation in DIBH technique; adjuvant systemic therapy was included if applicable. 106 (81.5%) patients received conventional and 24 (18.5%) hypofractionated irradiation"],"journal":["Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]"],"pagination":["379-388"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10033469"],"repository":["biostudies-literature"],"pubmed_title":["Deep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a single-institution retrospective dosimetric analysis of organs at risk doses."],"pmcid":["PMC10033469"],"pubmed_authors":["Krug D","Serpa M","Verma V","Lubke J","Gkika E","Grosu AL","Nicolay NH","Zamboglou C","Scholber J","Rothe T","Stoller S","Wolf J","Baltas D","Juhasz-Boss I","Sprave T"],"additional_accession":[]},"is_claimable":false,"name":"Deep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a single-institution retrospective dosimetric analysis of organs at risk doses.","description":"<h4>Background</h4>Radiotherapy can induce cardiac injury in left-sided breast cancer cases. Cardiac-sparing irradiation using the deep inspiration breath-hold (DIBH) technique can achieve substantial dose reduction to vulnerable cardiac substructures compared with free breathing (FB). This study evaluated the dosimetric differences between both techniques at a single institution.<h4>Methods</h4>From 2017 to 2019, 130 patients with left-sided breast cancer underwent breast-conserving surgery (BCS; n = 121, 93.1%) or mastectomy (ME; n = 9, 6.9%) along with axillary lymph node staging (n = 105, 80.8%), followed by adjuvant irradiation in DIBH technique; adjuvant systemic therapy was included if applicable. 106 (81.5%) patients received conventional and 24 (18.5%) hypofractionated irradiation","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-27T03:03:06.477Z","creation":"2025-04-06T18:45:30.279Z"},"accession":"S-EPMC10033469","cross_references":{"pubmed":["36074138"],"doi":["10.1007/s00066-022-01998-z"]}}