biostudies-literatureUnknown199(4)Wolf JUniversitätsklinikum Freiburg<h4>Background</h4>Radiotherapy can induce cardiac injury in left-sided breast cancer cases. Cardiac-sparing irradiation using the deep inspiration breath-hold (DIBH) technique can achieve substantial dose reduction to vulnerable cardiac substructures compared with free breathing (FB). This study evaluated the dosimetric differences between both techniques at a single institution.<h4>Methods</h4>From 2017 to 2019, 130 patients with left-sided breast cancer underwent breast-conserving surgery (BCS; n = 121, 93.1%) or mastectomy (ME; n = 9, 6.9%) along with axillary lymph node staging (n = 105, 80.8%), followed by adjuvant irradiation in DIBH technique; adjuvant systemic therapy was included if applicable. 106 (81.5%) patients received conventional and 24 (18.5%) hypofractionated irradiationStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]379-388https://www.ebi.ac.uk/biostudies/studies/S-EPMC10033469biostudies-literatureDeep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a single-institution retrospective dosimetric analysis of organs at risk doses.PMC10033469Krug DSerpa MVerma VLubke JGkika EGrosu ALNicolay NHZamboglou CScholber JRothe TStoller SWolf JBaltas DJuhasz-Boss ISprave TfalseDeep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a single-institution retrospective dosimetric analysis of organs at risk doses.<h4>Background</h4>Radiotherapy can induce cardiac injury in left-sided breast cancer cases. Cardiac-sparing irradiation using the deep inspiration breath-hold (DIBH) technique can achieve substantial dose reduction to vulnerable cardiac substructures compared with free breathing (FB). This study evaluated the dosimetric differences between both techniques at a single institution.<h4>Methods</h4>From 2017 to 2019, 130 patients with left-sided breast cancer underwent breast-conserving surgery (BCS; n = 121, 93.1%) or mastectomy (ME; n = 9, 6.9%) along with axillary lymph node staging (n = 105, 80.8%), followed by adjuvant irradiation in DIBH technique; adjuvant systemic therapy was included if applicable. 106 (81.5%) patients received conventional and 24 (18.5%) hypofractionated irradiation2023-01-01T00:00:00Z2023 Apr2025-04-27T03:03:06.477Z2025-04-06T18:45:30.279ZS-EPMC100334693607413810.1007/s00066-022-01998-z