{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Auld N"],"funding":["NIGMS NIH HHS"],"pagination":["876-884"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10035560"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["197(8)"],"pubmed_abstract":["This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells."],"journal":["Phosphorus, sulfur, and silicon and the related elements"],"pubmed_title":["A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985."],"pmcid":["PMC10035560"],"funding_grant_id":["T34 GM110517"],"pubmed_authors":["Auld N","Flood K","Cavnar PJ","Kesharwani T"],"additional_accession":[]},"is_claimable":false,"name":"A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985.","description":"This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-21T16:13:39.801Z","creation":"2025-04-21T16:13:39.801Z"},"accession":"S-EPMC10035560","cross_references":{"pubmed":["36970371"],"doi":["10.1080/10426507.2022.2085272"]}}