biostudies-literatureAuld NNIGMS NIH HHS876-884https://www.ebi.ac.uk/biostudies/studies/S-EPMC10035560biostudies-literatureUnknown197(8)This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells.Phosphorus, sulfur, and silicon and the related elementsA study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985.PMC10035560T34 GM110517Auld NFlood KCavnar PJKesharwani TfalseA study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985.This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells.2022-01-01T00:00:00Z20222025-04-21T16:13:39.801Z2025-04-21T16:13:39.801ZS-EPMC100355603697037110.1080/10426507.2022.2085272