{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun GQ"],"funding":["NIGMS NIH HHS"],"pagination":["67-72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10036166"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["615(7950)"],"pubmed_abstract":["Pyridines and related N-heteroarenes are commonly found in pharmaceuticals, agrochemicals and other biologically active compounds<sup>1,2</sup>. Site-selective C-H functionalization would provide a direct way of making these medicinally active products<sup>3-5</sup>. For example, nicotinic acid derivatives could be made by C-H carboxylation, but this remains an elusive transformation<sup>6-8</sup>. Here we describe the development of an electrochemical strategy for the direct carboxylation of pyridines using CO<sub>2</sub>. The choice of the electrolysis setup gives rise to divergent site selectivity: a divided electrochemical cell leads to C5 carboxylation, whereas an undivided cell promotes C4 carboxylation. The undivided-cell reaction is proposed to operate through a paired-electrolysis"],"journal":["Nature"],"pubmed_title":["Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations."],"pmcid":["PMC10036166"],"funding_grant_id":["R24 GM146107","P41 GM103521","R01 GM130928"],"pubmed_authors":["Zhang W","Lin S","Liao LL","Zhang Z","Yu P","Lu Z","Sun GQ","Wang Y","Yu DG","Li L"],"additional_accession":[]},"is_claimable":false,"name":"Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations.","description":"Pyridines and related N-heteroarenes are commonly found in pharmaceuticals, agrochemicals and other biologically active compounds<sup>1,2</sup>. Site-selective C-H functionalization would provide a direct way of making these medicinally active products<sup>3-5</sup>. For example, nicotinic acid derivatives could be made by C-H carboxylation, but this remains an elusive transformation<sup>6-8</sup>. Here we describe the development of an electrochemical strategy for the direct carboxylation of pyridines using CO<sub>2</sub>. The choice of the electrolysis setup gives rise to divergent site selectivity: a divided electrochemical cell leads to C5 carboxylation, whereas an undivided cell promotes C4 carboxylation. The undivided-cell reaction is proposed to operate through a paired-electrolysis","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-22T15:05:37.547Z","creation":"2025-04-06T01:18:31.113Z"},"accession":"S-EPMC10036166","cross_references":{"pubmed":["36603811"],"doi":["10.1038/s41586-022-05667-0"]}}