{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Placidi G"],"funding":["Associazione Italiana per la Ricerca sul Cancro"],"pubmed_abstract":["Over the past years a growing number of studies highlighted the pivotal role of intracellular trafficking in cell physiology. Among the distinct transport itineraries connecting the endocytic system, both internalization (endocytosis) and recycling (endocytic recycling) pathways were found fundamental to ensure cellular sensing, cell-to-cell communication, cellular division, and collective cell migration in tissue specific-contexts. Consistently, the dysregulation of endocytic trafficking pathways is correlated with several human diseases including both cancers and neurodegeneration. Aimed at suppress specific intracellular trafficking routes involved in disease onset and progression, huge efforts have been made to identify small molecule inhibitors with suitable pharmacological properties"],"journal":["Frontiers in cell and developmental biology"],"pagination":["1125801"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10036367"],"repository":["biostudies-literature"],"pubmed_title":["Small molecules targeting endocytic uptake and recycling pathways."],"pmcid":["PMC10036367"],"pubmed_authors":["Campa CC","Placidi G","Ciardelli G","Mattu C"],"additional_accession":[]},"is_claimable":false,"name":"Small molecules targeting endocytic uptake and recycling pathways.","description":"Over the past years a growing number of studies highlighted the pivotal role of intracellular trafficking in cell physiology. Among the distinct transport itineraries connecting the endocytic system, both internalization (endocytosis) and recycling (endocytic recycling) pathways were found fundamental to ensure cellular sensing, cell-to-cell communication, cellular division, and collective cell migration in tissue specific-contexts. Consistently, the dysregulation of endocytic trafficking pathways is correlated with several human diseases including both cancers and neurodegeneration. Aimed at suppress specific intracellular trafficking routes involved in disease onset and progression, huge efforts have been made to identify small molecule inhibitors with suitable pharmacological properties","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-21T14:39:35.423Z","creation":"2025-04-21T14:39:35.423Z"},"accession":"S-EPMC10036367","cross_references":{"pubmed":["36968200"],"doi":["10.3389/fcell.2023.1125801"]}}