{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(4)"],"submitter":["Sheik A"],"funding":["Inha University","National Research Foundation of Korea"],"pubmed_abstract":["<i>Basella alba</i>, a green leafy vegetable with remarkable nutraceutical potential is widely used since ancient times to maintain a healthy colon. This plant has been investigated for its medicinal potential due to the increase in young adult cases of colorectal cancer each year. This study was accomplished to investigate <i>Basella alba </i>methanolic extract (BaME) antioxidant and anticancer properties. BaME consisted of a substantial amount of both phenolic and flavonoid compounds which exhibited significant antioxidant reactivity. Both colon cancer cell lines experienced a cell cycle arrest at the G0/G1 phase after receiving treatment with BaME, which inhibited pRb and cyclin D1 and raised p21 expression levels. This was associated with the survival pathway molecule inhibition and do"],"journal":["Saudi journal of biological sciences"],"pagination":["103609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10036729"],"repository":["biostudies-literature"],"pubmed_title":["Antioxidant and antiproliferative activity of <i>Basella alba</i> against colorectal cancer."],"pmcid":["PMC10036729"],"pubmed_authors":["Huh YS","Kim E","Alhammadi M","Adepelly U","Sheik A"],"additional_accession":[]},"is_claimable":false,"name":"Antioxidant and antiproliferative activity of <i>Basella alba</i> against colorectal cancer.","description":"<i>Basella alba</i>, a green leafy vegetable with remarkable nutraceutical potential is widely used since ancient times to maintain a healthy colon. This plant has been investigated for its medicinal potential due to the increase in young adult cases of colorectal cancer each year. This study was accomplished to investigate <i>Basella alba </i>methanolic extract (BaME) antioxidant and anticancer properties. BaME consisted of a substantial amount of both phenolic and flavonoid compounds which exhibited significant antioxidant reactivity. Both colon cancer cell lines experienced a cell cycle arrest at the G0/G1 phase after receiving treatment with BaME, which inhibited pRb and cyclin D1 and raised p21 expression levels. This was associated with the survival pathway molecule inhibition and do","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-07-08T03:10:33.092Z","creation":"2025-04-07T04:52:47.345Z"},"accession":"S-EPMC10036729","cross_references":{"pubmed":["36970255"],"doi":["10.1016/j.sjbs.2023.103609"]}}