biostudies-literatureUnknown30(4)Sheik AInha UniversityNational Research Foundation of Korea<i>Basella alba</i>, a green leafy vegetable with remarkable nutraceutical potential is widely used since ancient times to maintain a healthy colon. This plant has been investigated for its medicinal potential due to the increase in young adult cases of colorectal cancer each year. This study was accomplished to investigate <i>Basella alba </i>methanolic extract (BaME) antioxidant and anticancer properties. BaME consisted of a substantial amount of both phenolic and flavonoid compounds which exhibited significant antioxidant reactivity. Both colon cancer cell lines experienced a cell cycle arrest at the G0/G1 phase after receiving treatment with BaME, which inhibited pRb and cyclin D1 and raised p21 expression levels. This was associated with the survival pathway molecule inhibition and doSaudi journal of biological sciences103609https://www.ebi.ac.uk/biostudies/studies/S-EPMC10036729biostudies-literatureAntioxidant and antiproliferative activity of <i>Basella alba</i> against colorectal cancer.PMC10036729Huh YSKim EAlhammadi MAdepelly USheik AfalseAntioxidant and antiproliferative activity of <i>Basella alba</i> against colorectal cancer.<i>Basella alba</i>, a green leafy vegetable with remarkable nutraceutical potential is widely used since ancient times to maintain a healthy colon. This plant has been investigated for its medicinal potential due to the increase in young adult cases of colorectal cancer each year. This study was accomplished to investigate <i>Basella alba </i>methanolic extract (BaME) antioxidant and anticancer properties. BaME consisted of a substantial amount of both phenolic and flavonoid compounds which exhibited significant antioxidant reactivity. Both colon cancer cell lines experienced a cell cycle arrest at the G0/G1 phase after receiving treatment with BaME, which inhibited pRb and cyclin D1 and raised p21 expression levels. This was associated with the survival pathway molecule inhibition and do2023-01-01T00:00:00Z2023 Apr2025-07-08T03:10:33.092Z2025-04-07T04:52:47.345ZS-EPMC100367293697025510.1016/j.sjbs.2023.103609