{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu X"],"funding":["Swiss National Science Foundation"],"pagination":["6270-6279"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10037331"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(11)"],"pubmed_abstract":["An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of aryl aziridines with alkenyl bromides has been developed, affording enantioenriched β-aryl homoallylic amines with excellent <i>E</i>-selectivity. This electroreductive strategy proceeds in the absence of heterogeneous metal reductants and sacrificial anodes by employing constant current electrolysis in an undivided cell with triethylamine as a terminal reductant. The reaction features mild conditions, remarkable stereocontrol, broad substrate scope, and excellent functional group compatibility, which was illustrated by the late-stage functionalization of bioactive molecules. Mechanistic studies indicate that this transformation conforms with a stereoconvergent mechanism in which the aziridine is activated through a nucleophilic halide ring-opening process."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Nickel-Catalyzed Enantioselective Electrochemical Reductive Cross-Coupling of Aryl Aziridines with Alkenyl Bromides."],"pmcid":["PMC10037331"],"funding_grant_id":["184986","200021_184986/1"],"pubmed_authors":["Nevado C","Hu X","Cuesta-Galisteo S","Cheng-Sanchez I"],"additional_accession":[]},"is_claimable":false,"name":"Nickel-Catalyzed Enantioselective Electrochemical Reductive Cross-Coupling of Aryl Aziridines with Alkenyl Bromides.","description":"An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of aryl aziridines with alkenyl bromides has been developed, affording enantioenriched β-aryl homoallylic amines with excellent <i>E</i>-selectivity. This electroreductive strategy proceeds in the absence of heterogeneous metal reductants and sacrificial anodes by employing constant current electrolysis in an undivided cell with triethylamine as a terminal reductant. The reaction features mild conditions, remarkable stereocontrol, broad substrate scope, and excellent functional group compatibility, which was illustrated by the late-stage functionalization of bioactive molecules. Mechanistic studies indicate that this transformation conforms with a stereoconvergent mechanism in which the aziridine is activated through a nucleophilic halide ring-opening process.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-07-08T03:10:31.144Z","creation":"2025-04-07T04:56:04.48Z"},"accession":"S-EPMC10037331","cross_references":{"pubmed":["36881734"],"doi":["10.1021/jacs.2c12869"]}}