biostudies-literatureMcCarthy CNHLBI NIH HHS207-219https://www.ebi.ac.uk/biostudies/studies/S-EPMC10037558biostudies-literatureUnknown81(3)<h4>Background</h4>Few data exist regarding the implementation of high-sensitivity cardiac troponin (hs-cTn) assays in the United States since their approval.<h4>Objectives</h4>This study sought to explore trends in hs-cTn assay implementation over time and assess the association of their use with in-hospital cardiac testing and outcomes.<h4>Methods</h4>The study examined trends in implementation of hs-cTn assays among participating hospitals in the National Cardiovascular Data Registry Chest Pain-MI [Myocardial Infarction] Registry from January 1, 2019 through September 30, 2021. Associations among hs-cTn use, use of in-hospital diagnostic imaging, and patient outcomes were assessed using generalized estimating equation models with logistic or gamma distributions.<h4>Results</h4>Among 550Journal of the American College of CardiologyImplementation of High-Sensitivity Cardiac Troponin Assays in the United States.PMC10037558K23 HL150315T32 HL094301Wang TYde Lemos JAJaffe ASSandoval YJanuzzi JLRaber ILi SWasfy JHApple FSNewby LKKontos MCSmilowitz NRPandey ADaniels LBMcCarthy CfalseImplementation of High-Sensitivity Cardiac Troponin Assays in the United States.<h4>Background</h4>Few data exist regarding the implementation of high-sensitivity cardiac troponin (hs-cTn) assays in the United States since their approval.<h4>Objectives</h4>This study sought to explore trends in hs-cTn assay implementation over time and assess the association of their use with in-hospital cardiac testing and outcomes.<h4>Methods</h4>The study examined trends in implementation of hs-cTn assays among participating hospitals in the National Cardiovascular Data Registry Chest Pain-MI [Myocardial Infarction] Registry from January 1, 2019 through September 30, 2021. Associations among hs-cTn use, use of in-hospital diagnostic imaging, and patient outcomes were assessed using generalized estimating equation models with logistic or gamma distributions.<h4>Results</h4>Among 5502023-01-01T00:00:00Z2023 Jan2025-04-03T23:49:51.829Z2025-04-03T23:49:51.829ZS-EPMC100375583632815510.1016/j.jacc.2022.10.017