biostudies-literatureKogon AJNIDDK NIH HHSNIDDK1257-1266https://www.ebi.ac.uk/biostudies/studies/S-EPMC10044533biostudies-literatureUnknown38(4)<h4>Background</h4>Obesity is prevalent among children with chronic kidney disease (CKD) and is associated with cardiovascular disease and reduced quality of life. Its relationship with pediatric CKD progression has not been described.<h4>Methods</h4>We evaluated relationships between both body mass index (BMI) category (normal, overweight, obese) and BMI z-score (BMIz) change on CKD progression among participants of the Chronic Kidney Disease in Children study. Kaplan-Meier survival curves and multivariable parametric failure time models depict the association of baseline BMI category on time to kidney replacement therapy (KRT). Additionally, the annualized percentage change in estimated glomerular filtration rate (eGFR) was modeled against concurrent change in BMIz using multivariable liPediatric nephrology (Berlin, Germany)Associations of body mass index (BMI) and BMI change with progression of chronic kidney disease in children.PMC10044533U24-DK-082194U24-DK66116U01 DK066174U01 DK066143U24 DK082194U24 DK066116U01-DK-66174U01- DK-66143Mitsnefes MMFurth SLRodig NMRoem JSchneider MFZemel BSWarady BAKogon AJfalseAssociations of body mass index (BMI) and BMI change with progression of chronic kidney disease in children.<h4>Background</h4>Obesity is prevalent among children with chronic kidney disease (CKD) and is associated with cardiovascular disease and reduced quality of life. Its relationship with pediatric CKD progression has not been described.<h4>Methods</h4>We evaluated relationships between both body mass index (BMI) category (normal, overweight, obese) and BMI z-score (BMIz) change on CKD progression among participants of the Chronic Kidney Disease in Children study. Kaplan-Meier survival curves and multivariable parametric failure time models depict the association of baseline BMI category on time to kidney replacement therapy (KRT). Additionally, the annualized percentage change in estimated glomerular filtration rate (eGFR) was modeled against concurrent change in BMIz using multivariable li2023-01-01T00:00:00Z2023 Apr2025-04-04T19:58:47.136Z2025-04-04T19:58:47.136ZS-EPMC100445333601843310.1007/s00467-022-05655-6