{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khan UB"],"funding":["Rosetrees","Wellcome Trust"],"pagination":["544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10044541"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["<i>Streptococcus agalactiae</i> or group B streptococcus (GBS) is a leading cause of neonatal sepsis and increasingly found as an invasive pathogen in older patient populations. Beta-lactam antibiotics remain the most effective therapeutic with resistance rarely reported, while the majority of GBS isolates carry the tetracycline resistance gene <i>tet(M)</i> in fixed genomic positions amongst five predominant clonal clades. In the UK, GBS resistance to clindamycin and erythromycin has increased from 3% in 1991 to 11.9% (clindamycin) and 20.2% (erythromycin), as reported in this study. Here, a systematic investigation of antimicrobial resistance genomic content sought to fully characterise the associated mobile genetic elements within phenotypically resistant GBS isolates from 193 invasive "],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["Genomic Analysis Reveals New Integrative Conjugal Elements and Transposons in GBS Conferring Antimicrobial Resistance."],"pmcid":["PMC10044541"],"funding_grant_id":["M683"],"pubmed_authors":["Spiller OB","Sands K","Lo S","Khan UB","Jauneikaite E","Portal EAR","Chalker VJ"],"additional_accession":[]},"is_claimable":false,"name":"Genomic Analysis Reveals New Integrative Conjugal Elements and Transposons in GBS Conferring Antimicrobial Resistance.","description":"<i>Streptococcus agalactiae</i> or group B streptococcus (GBS) is a leading cause of neonatal sepsis and increasingly found as an invasive pathogen in older patient populations. Beta-lactam antibiotics remain the most effective therapeutic with resistance rarely reported, while the majority of GBS isolates carry the tetracycline resistance gene <i>tet(M)</i> in fixed genomic positions amongst five predominant clonal clades. In the UK, GBS resistance to clindamycin and erythromycin has increased from 3% in 1991 to 11.9% (clindamycin) and 20.2% (erythromycin), as reported in this study. Here, a systematic investigation of antimicrobial resistance genomic content sought to fully characterise the associated mobile genetic elements within phenotypically resistant GBS isolates from 193 invasive ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-04-08T14:17:27.706Z","creation":"2025-02-19T02:38:23.495Z"},"accession":"S-EPMC10044541","cross_references":{"pubmed":["36978411"],"doi":["10.3390/antibiotics12030544"]}}