biostudies-literatureKhan UBRosetreesWellcome Trust544https://www.ebi.ac.uk/biostudies/studies/S-EPMC10044541biostudies-literatureUnknown12(3)<i>Streptococcus agalactiae</i> or group B streptococcus (GBS) is a leading cause of neonatal sepsis and increasingly found as an invasive pathogen in older patient populations. Beta-lactam antibiotics remain the most effective therapeutic with resistance rarely reported, while the majority of GBS isolates carry the tetracycline resistance gene <i>tet(M)</i> in fixed genomic positions amongst five predominant clonal clades. In the UK, GBS resistance to clindamycin and erythromycin has increased from 3% in 1991 to 11.9% (clindamycin) and 20.2% (erythromycin), as reported in this study. Here, a systematic investigation of antimicrobial resistance genomic content sought to fully characterise the associated mobile genetic elements within phenotypically resistant GBS isolates from 193 invasive Antibiotics (Basel, Switzerland)Genomic Analysis Reveals New Integrative Conjugal Elements and Transposons in GBS Conferring Antimicrobial Resistance.PMC10044541M683Spiller OBSands KLo SKhan UBJauneikaite EPortal EARChalker VJfalseGenomic Analysis Reveals New Integrative Conjugal Elements and Transposons in GBS Conferring Antimicrobial Resistance.<i>Streptococcus agalactiae</i> or group B streptococcus (GBS) is a leading cause of neonatal sepsis and increasingly found as an invasive pathogen in older patient populations. Beta-lactam antibiotics remain the most effective therapeutic with resistance rarely reported, while the majority of GBS isolates carry the tetracycline resistance gene <i>tet(M)</i> in fixed genomic positions amongst five predominant clonal clades. In the UK, GBS resistance to clindamycin and erythromycin has increased from 3% in 1991 to 11.9% (clindamycin) and 20.2% (erythromycin), as reported in this study. Here, a systematic investigation of antimicrobial resistance genomic content sought to fully characterise the associated mobile genetic elements within phenotypically resistant GBS isolates from 193 invasive 2023-01-01T00:00:00Z2023 Mar2026-04-08T14:17:27.706Z2025-02-19T02:38:23.495ZS-EPMC100445413697841110.3390/antibiotics12030544