{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iurescia M"],"funding":["the European Union's Horizon 2020 Re-search and Innovation programme","European Union","EMIDA ERA-NET (FP7-KBBE) first transnational research call","Methicillin-resistant Staphylococcus aureus lineages in pri-mary productions: multi-host pathogen, spill-over and spill-back between animals and hu-mans?","European Union’s Horizon 2020 Research and Innovation programme"],"pagination":["530"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10044604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["The <i>cfr</i> genes encode for a 23S rRNA methyltransferase, conferring a multiresistance phenotype to phenicol, lincosamide, oxazolidinone, pleuromutilin, and streptogramin A antibiotics. These genes have been described in staphylococci, including methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). In this study, we retrospectively performed an in-depth genomic characterisation of three <i>cfr</i>-positive, multidrug-resistant (MDR) livestock-associated (LA) MRSA clonal complexes (CCs) 1 and 398 detected in different Italian pig holdings (2008-2011) during population studies on Italian livestock (2008-2014). We used a combined Illumina and Oxford Nanopore Technologies (ONT) whole genome sequencing (WGS) approach on two isolates (the 2008 CC1 and the 2010 CC398 isolates, but not th"],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["Genomics Insight into <i>cfr</i>-Mediated Linezolid-Resistant LA-MRSA in Italian Pig Holdings."],"pmcid":["PMC10044604"],"funding_grant_id":["68","No 773830: One Health European Joint Programme.","EMIDA ERA-NET (FP7-KBBE) first transnational research call, Project Title: \"Methicillin-resistant Staphylococcus aureus lineages in primary productions: multi-host pathogen, spill-over and spill-back between animals and humans?\", \"LA-MRSA\" (acronym title)","773830","\"LA-MRSA\" (acronym title) ID 68."],"pubmed_authors":["Iurescia M","Alba P","Buccella C","Carfora V","Diaconu EL","Caprioli A","Giacomi A","Franco A","Feltrin F","Onorati R","Battisti A"],"additional_accession":[]},"is_claimable":false,"name":"Genomics Insight into <i>cfr</i>-Mediated Linezolid-Resistant LA-MRSA in Italian Pig Holdings.","description":"The <i>cfr</i> genes encode for a 23S rRNA methyltransferase, conferring a multiresistance phenotype to phenicol, lincosamide, oxazolidinone, pleuromutilin, and streptogramin A antibiotics. These genes have been described in staphylococci, including methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). In this study, we retrospectively performed an in-depth genomic characterisation of three <i>cfr</i>-positive, multidrug-resistant (MDR) livestock-associated (LA) MRSA clonal complexes (CCs) 1 and 398 detected in different Italian pig holdings (2008-2011) during population studies on Italian livestock (2008-2014). We used a combined Illumina and Oxford Nanopore Technologies (ONT) whole genome sequencing (WGS) approach on two isolates (the 2008 CC1 and the 2010 CC398 isolates, but not th","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-04-08T13:57:43.871Z","creation":"2024-11-12T20:47:32.086Z"},"accession":"S-EPMC10044604","cross_references":{"pubmed":["36978397"],"doi":["10.3390/antibiotics12030530"]}}