{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["National Research Foundation of Korea","Korea government (MSIT)"],"pagination":["640"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10045306"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["Metallothionein 3 (MT3), also known as a neuronal growth-inhibitory factor, is a member of the metallothionein family and is involved in a variety of biological functions, including protection against metal toxicity and reactive oxygen species (ROS). However, less is known about the role of MT3 in the differentiation of 3T3-L1 cells into adipocytes. In this study, we observed that MT3 levels were downregulated during 3T3-L1 adipocyte differentiation. <i>Mt3</i> overexpression inhibited adipocyte differentiation and reduced the levels of the adipogenic transcription factors C/EBPα and PPARγ. Further analyses showed that MT3 also suppressed the transcriptional activity of PPARγ, and this effect was not mediated by a direct interaction between MT3 with PPARγ. In addition, <i>Mt3</i> overexpre"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Metallothionein 3 Inhibits 3T3-L1 Adipocyte Differentiation via Reduction of Reactive Oxygen Species."],"pmcid":["PMC10045306"],"funding_grant_id":["2021R1I1A1A01052824","2021R1I1A3049062","2019R1A5A2027521"],"pubmed_authors":["Li Y","Lee SH","Kim HS","Lee KY","Piao M"],"additional_accession":[]},"is_claimable":false,"name":"Metallothionein 3 Inhibits 3T3-L1 Adipocyte Differentiation via Reduction of Reactive Oxygen Species.","description":"Metallothionein 3 (MT3), also known as a neuronal growth-inhibitory factor, is a member of the metallothionein family and is involved in a variety of biological functions, including protection against metal toxicity and reactive oxygen species (ROS). However, less is known about the role of MT3 in the differentiation of 3T3-L1 cells into adipocytes. In this study, we observed that MT3 levels were downregulated during 3T3-L1 adipocyte differentiation. <i>Mt3</i> overexpression inhibited adipocyte differentiation and reduced the levels of the adipogenic transcription factors C/EBPα and PPARγ. Further analyses showed that MT3 also suppressed the transcriptional activity of PPARγ, and this effect was not mediated by a direct interaction between MT3 with PPARγ. In addition, <i>Mt3</i> overexpre","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-04-08T14:15:35.608Z","creation":"2025-02-19T02:38:39.518Z"},"accession":"S-EPMC10045306","cross_references":{"pubmed":["36978888"],"doi":["10.3390/antiox12030640"]}}