{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Banfi C"],"funding":["Ministero della Salute","Italian Ministry of Health, Italy, Ricerca Corrente 2021, Centro Cardiologico Monzino IRCCS"],"pagination":["542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10045348"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["The process of adipogenesis involves the differentiation of preadipocytes into mature adipocytes. Excessive adipogenesis promotes obesity, a condition that increasingly threatens global health and contributes to the rapid rise of obesity-related diseases. We have recently shown that prenylcysteine oxidase 1 (PCYOX1) is a regulator of atherosclerosis-disease mechanisms, which acts through mechanisms not exclusively related to its pro-oxidant activity. To address the role of PCYOX1 in the adipogenic process, we extended our previous observations confirming that Pcyox1<sup>-/-</sup>/Apoe<sup>-/-</sup> mice fed a high-fat diet for 8 or 12 weeks showed significantly lower body weight, when compared to Pcyox1<sup>+/+</sup>/Apoe<sup>-/-</sup> mice, due to an evident reduction in visceral adipose "],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Prenylcysteine Oxidase 1 Is a Key Regulator of Adipogenesis."],"pmcid":["PMC10045348"],"funding_grant_id":["RF 2013-02355543"],"pubmed_authors":["Gianazza E","Baetta R","Mallia A","Banfi C","Brioschi M","Sahlen P","Ghilardi S","Eligini S"],"additional_accession":[]},"is_claimable":false,"name":"Prenylcysteine Oxidase 1 Is a Key Regulator of Adipogenesis.","description":"The process of adipogenesis involves the differentiation of preadipocytes into mature adipocytes. Excessive adipogenesis promotes obesity, a condition that increasingly threatens global health and contributes to the rapid rise of obesity-related diseases. We have recently shown that prenylcysteine oxidase 1 (PCYOX1) is a regulator of atherosclerosis-disease mechanisms, which acts through mechanisms not exclusively related to its pro-oxidant activity. To address the role of PCYOX1 in the adipogenic process, we extended our previous observations confirming that Pcyox1<sup>-/-</sup>/Apoe<sup>-/-</sup> mice fed a high-fat diet for 8 or 12 weeks showed significantly lower body weight, when compared to Pcyox1<sup>+/+</sup>/Apoe<sup>-/-</sup> mice, due to an evident reduction in visceral adipose ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-04-08T14:13:01.632Z","creation":"2025-02-19T02:38:37.48Z"},"accession":"S-EPMC10045348","cross_references":{"pubmed":["36978789"],"doi":["10.3390/antiox12030542"]}}