biostudies-literatureBanfi CMinistero della SaluteItalian Ministry of Health, Italy, Ricerca Corrente 2021, Centro Cardiologico Monzino IRCCS542https://www.ebi.ac.uk/biostudies/studies/S-EPMC10045348biostudies-literatureUnknown12(3)The process of adipogenesis involves the differentiation of preadipocytes into mature adipocytes. Excessive adipogenesis promotes obesity, a condition that increasingly threatens global health and contributes to the rapid rise of obesity-related diseases. We have recently shown that prenylcysteine oxidase 1 (PCYOX1) is a regulator of atherosclerosis-disease mechanisms, which acts through mechanisms not exclusively related to its pro-oxidant activity. To address the role of PCYOX1 in the adipogenic process, we extended our previous observations confirming that Pcyox1^-/-/Apoe^-/- mice fed a high-fat diet for 8 or 12 weeks showed significantly lower body weight, when compared to Pcyox1^+/+/Apoe^-/- mice, due to an evident reduction in visceral adipose Antioxidants (Basel, Switzerland)Prenylcysteine Oxidase 1 Is a Key Regulator of Adipogenesis.PMC10045348RF 2013-02355543Gianazza EBaetta RMallia ABanfi CBrioschi MSahlen PGhilardi SEligini SfalsePrenylcysteine Oxidase 1 Is a Key Regulator of Adipogenesis.The process of adipogenesis involves the differentiation of preadipocytes into mature adipocytes. Excessive adipogenesis promotes obesity, a condition that increasingly threatens global health and contributes to the rapid rise of obesity-related diseases. We have recently shown that prenylcysteine oxidase 1 (PCYOX1) is a regulator of atherosclerosis-disease mechanisms, which acts through mechanisms not exclusively related to its pro-oxidant activity. To address the role of PCYOX1 in the adipogenic process, we extended our previous observations confirming that Pcyox1^-/-/Apoe^-/- mice fed a high-fat diet for 8 or 12 weeks showed significantly lower body weight, when compared to Pcyox1^+/+/Apoe^-/- mice, due to an evident reduction in visceral adipose 2023-01-01T00:00:00Z2023 Feb2026-04-08T14:13:01.632Z2025-02-19T02:38:37.48ZS-EPMC100453483697878910.3390/antiox12030542