{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","Natural Science Foundation of Guangdong Province","National Natural Science Foundation of China"],"pagination":["1133-1146"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10045874"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["97(4)"],"pubmed_abstract":["Intestinal organoid may serve as an alternative model for toxicity testing. However, the linkage between specific morphological alterations in organoids and chemical-induced toxicity has yet to be defined. Here, we generated C57BL/6 mouse intestinal organoids and conducted a morphology-based analysis on chemical-induced toxicity. Alterations in morphology were characterized by large spheroids, hyperplastic organoids, small spheroids, and protrusion-loss organoids, which responded in a concentration-dependent manner to the treatment of four metal(loid)s including cadmium (Cd), lead (Pb), hexavalent chromium (Cr-VI), and inorganic trivalent arsenic (iAs-III). Notably, alterations in organoid morphology characterized by abnormal morphology rate were correlated with specific intestinal toxic e"],"journal":["Archives of toxicology"],"pubmed_title":["Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical-induced toxicity."],"pmcid":["PMC10045874"],"funding_grant_id":["2021A1515010350","82204080","R01 ES10563","R01 ES007331","82073580","R01 ES07331"],"pubmed_authors":["Guo Z","Li D","Xing X","Chen L","Pang Y","Zhang R","Zhang Q","Li M","Jiang Y","Ye L","Aschner M","Jiang X","Chen W","Chen S","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical-induced toxicity.","description":"Intestinal organoid may serve as an alternative model for toxicity testing. However, the linkage between specific morphological alterations in organoids and chemical-induced toxicity has yet to be defined. Here, we generated C57BL/6 mouse intestinal organoids and conducted a morphology-based analysis on chemical-induced toxicity. Alterations in morphology were characterized by large spheroids, hyperplastic organoids, small spheroids, and protrusion-loss organoids, which responded in a concentration-dependent manner to the treatment of four metal(loid)s including cadmium (Cd), lead (Pb), hexavalent chromium (Cr-VI), and inorganic trivalent arsenic (iAs-III). Notably, alterations in organoid morphology characterized by abnormal morphology rate were correlated with specific intestinal toxic e","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-26T19:39:57.128Z","creation":"2025-04-06T16:12:14.877Z"},"accession":"S-EPMC10045874","cross_references":{"pubmed":["36806895"],"doi":["10.1007/s00204-023-03451-1"]}}